Dr. Li, Ling-Hui 's publons link picture

Dr. Li, Ling-Hui

Research Scientist
  • 02-2789-9078 (Lab) (Room No: N618)

  • Cancer Genomics
  • Human Molecular Genetics

Education and Positions:
  • Ph.D, State University of New York at Stony Brook, USA

Genome-wide SNP genotyping is a valuable tool for the identification of genes related to disease susceptibility and adverse drug reactions. One of my duties as a research scientist is to ensure the quality of whole genome SNP genotyping service provided by the National Center for Genome Medicine at Academia Sinica. In addition to these routine services, I am actively involved in technological R&D to maximize the utility of SNP genotyping array data. First, I collaborated with statisticians to develop analysis tools to detect interesting genomic features which have not yet been covered by commercial analysis tools. The most recently developed software, ALICE, is awarded the Minister of Science and Technology prize of “2018 Future Tech”. Second, I collaborated with physicians to apply SNP genotyping technology for detecting copy number variation/alteration in neuropsychiatric diseases, induced pluripotent stem cell lines and cancers. Third, I participated in the development of customized Axiom array plates including TPM (TWB2.0) and TPM2 that are designed for genetic study focusing on the Han Chinese residing in Taiwan.

The focus of my research work is to discover the genetic factors and microbes contributing to the malignant transformation of colorectal adenoma to colorectal carcinoma (CRC).​​​​​​​ We have identified several candidate tumor-related genes by integrative analysis of genomic and transcriptomic data. Among them, SKA3 at chromosome 13q was identified as a novel gene in promoting malignant transformation of CRC. Overexpression of these genes may lead to higher chromosomal instability (CIN) in tumors and render them prone to malignant transformation. Currently, we are investigating the underlying mechanisms of these genes contributing to tumorigenesis and progression of CRC. We will also evaluate whether the candidate genes can serve as biomarkers for diagnosis and/or disease monitoring. With 16S rRNA sequencing of paired tissue samples from patients with CRC, we observed that the relative abundance of several microbes was higher in cancerous tissues than in paired adenomas and normal colon tissues. The interactions among these microbes and host and the tumorigenesis mechanisms induced by these interactions will be the focus in the next few years.

  1. Chia-Hui Lo, Deng-Chyang Wu, Shu-Wen Jao, Chang-Chieh Wu, Chung-Yen Lin, Chia-Hsien Chuang, Ya-Bo Lin, Chien-Hsiun Chen, Ying-Ting Chen, Jiann-Hwa Chen, Koung-Hung Hsiao, Ying-Ju Chen, Yuan-Tsong Chen, Jaw-Yuan Wang*, (Ling-Hui Li)* Enrichment of Prevotella intermedia in human colorectal cancer and its additive effects with Fusobacterium nucleatum on the malignant transformation of colorectal adenomas JOURNAL OF BIOMEDICAL SCIENCE 29, 88 (2022-10-27) [JCR] [WOS]
  2. Binay K. Sahoo, Yuh-Charn Lin, Cheng-Fen Tu, Chien-Chin Lin, Wei-Ju Liao, Fu-An Li, (Ling-Hui Li), Yun Mou, Steve R. Roffler, Shu-Ping Wang, Chi-Tai Yeh, Chi-Yuan Yao, Hsin-An Hou, Wen-Chien Chou, Hwei-Fang Tien, Ruey-Bing Yang* Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia Haematologica (2022-08-25) [JCR] [WOS]
  3. Cheng-Fen Tu, Fu-An Li, (Ling-Hui Li) and Ruey-Bing Yang* Quantitative glycoproteomics analysis identifies novel FUT8 targets and signaling networks critical for breast cancer cell invasiveness BREAST CANCER RESEARCH 24, 21 (2022-03) [JCR] [WOS]
  4. Wei Chun-Yu, Yang Jenn-Hwai, Yeh Erh-Chan, Tsai Ming-Fang, Kao Hsiao-Jung, Lo Chen-Zen, Chang Lung-Pao, Lin Wan-Jia, Hsieh Feng-Jen, Belsare Saurabh, Bhaskar Anand, Su Ming-Wei, Lee Te-Chang, Lin Yi-Ling, Liu Fu-Tong, Shen Chen-Yang, (Li Ling-Hui), Chen Chien-Hsiun, Wall Jeffrey D., Wu Jer-Yuarn, Kwok Pui-Yan* Genetic profiles of 103,106 individuals in the Taiwan Biobank provide insights into the health and history of Han Chinese npj Genomic Medicine 6(1), 10 (2021-02) [JCR] [WOS]
  5. Chen Yen-Cheng, Miao Zhi-Feng, Yip Kwan-Ling, Cheng Yi-An, Liu Chung-Jung, (Li Ling-Hui), Lin Chung-Yen, Wang Jiunn-Wei, Wu Deng-Chyang, Cheng Tian-Lu, Wang Jaw-Yuan* Gut Fecal Microbiota Transplant in a Mouse Model of Orthotopic Rectal Cancer Frontiers in Oncology 10, 568012 (2020-10) [JCR] [WOS]
  6. Huang Ching-Ying, (Li Ling-Hui), Hsu Wan-Tseng, Cheng Yu-Che, Nicholson Martin W., Liu Chun-Lin, Ting Chien-Yu, Ko Hui-Wen, Syu Shih-Han, Wen Cheng-Hao, Yan Zhuge, Huang Hsiang-Po, Su Hong-Lin, Chiang Po-Min, Shen Chia-Ning, Chen Hsin-Fu, Yen B. Lin Ju, Lu Huai-En, Hwang Shiaw-Min, Chiou Shih-Hwa, Ho Hong-Nerng, Wu Jer-Yuarn, Kamp Timothy J., Wu Joseph C., Hsieh Patrick C. H.* Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines - lessons from establishing the Taiwan human disease iPSC Consortium Bank Journal of Biomedical Science 27(1), 92 (2020-09) [JCR] [WOS]
  7. Shen Wen-Ching, Lai Yung-Chih, (Li Ling-Hui), Liao Kolin, Lai Hung-Chang, Kao Shou-Yen, Wang John, Chuong Cheng-Ming, Hung Shih-Chieh* Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis Nature Communications 10(1), 2226 (2019-05) [JCR] [WOS]
  8. Chen CH, Chen HI, Chien WH, (Li LH), Wu YY, Chiu YN, Tsai WC, Gau SS* High resolution analysis of rare copy number variants in patients with autism spectrum disorder from Taiwan Scientific reports 7(1), 11919 (2017-09) [JCR] [WOS]
  9. Chuang, T.P., Wang, J.Y., Jao, S.W., Wu, C.C., Chen, J.H., Hsiao, K.H., Lin, C.Y., Chen, S.H., Su, S.Y., Chen, Y.J., Chen, Y.T., Wu, D.C.*, (Li, L.H.)* Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression. Oncotarget 7(29), 45803-45818 (2016-06) [JCR] [WOS]
  10. Lin, Y.-F., (Li, L.-H.), Lin, C.-H., Tsou, M.-H., Chuang, M.-T.K., Wu, K.-M., Liao, T.-L., Li, J.-C., Wang, W.-J., Tomita, A., Tomita, B., Huang, S.-F., Tsai, S.-F.* Selective Retention of an Inactive Allele of the DKK2 Tumor Suppressor Gene in Hepatocellular Carcinoma PLoS Genetics 12, e1006051 (2016-05) [JCR] [WOS]

Lo, Chia-Hui
Lee Shen, Yang
Chuang, Tzu-Po