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Dr. Fann, Cathy S.-J.

Research Fellow
  • 02-27899144 (Lab) (Room No: 100)
  • 02-27823047 (Fax)

Specialty:
  • Genetic Statistics
  • Genetic Epidemiology

Education and Positions:
  • Division of Biostatistics, Department of Preventive Medicine and Environmental Health,
    Ph.D. University of Iowa, Iowa City, Iowa, US


Dr. Cathy S.J. Fann specializes in genetic epidemiology and biostatistics, leveraging biobank data, machine learning, and statistical genetics to advance precision medicine. Her research spans neurological, psychiatric, and respiratory diseases, focusing on migraine, Alzheimer's, schizophrenia, and asthma.

Key Findings:

* Migraine, Cluster Headache and Vertigo: Identified novel genetic risk loci through GWAS and bioinformatic tools in Han Chinese populations.

* Alzheimer's Disease: Developed refined risk models incorporating APOE ε4 allele and PM2.5 exposure.

* Polygenic Risk Scores (PRS): Improved disease risk prediction and treatment stratification.

 

Current Projects:

1. Asthma Subtypes: Using AI to classify phenotypic and genetic clusters for personalized treatment.

2. Taiwan Precision Medicine Initiative: Enhancing PRS applications in clinical practice.

3. Chronic Migraine Research: Multi-omics integration to identify novel therapeutic targets.

Research Highlights:

* Developed statistical techniques for rare variant analysis and synthetic haplotype generation.

* Contributed to genetic screening policies and public health initiatives.

* Advocate for Open Science and genomic data sharing.

 

Selected Publications:

1. Lim AM et al. (2024). Metabolic Syndrome Endophenotypes in UK and Taiwan Biobanks. iScience. DOI: 10.1016/j.isci.2024.109815

2. Chen SP et al. (2024). GWAS Identifies Novel Loci for Vertigo. Communications Biology.

3. Cheng YW et al. (2023). APOE Genotype & Cognitive Impairment. J Am Heart Assoc.

4. Winsvold BS et al. (2023). Cluster Headache GWAS Identifies Eight Loci. Ann Neurol.

5. Lee CJ et al. (2022). Taiwan Biobank Analysis on Glycemia-related Loci. Communications Biology.

For a full list, visit ORCID profile   or IBMS Research Archive System (RAS).

Our Team
Team photo

Journal 148 Book 2

  1. Ting-Huei Chen, Chia-Jung Lee, Syue-Pu Chen, Shang-Jung Wu and Cathy SJ Fann PNL: a software to build polygenic risk scores using a Super Learner approach based on PairNet, a Convolutional Neural Network. Bioinformatics 2025, 2025-2025 (2025-02) [JCR] [WOS]
  2. Chen SP, Hsu CL, Chen TH, Pan LH, Wang YF, Ling YH, Chang HC, Chen YM, Fann CS, Wang SJ A genome-wide association study identifies novel loci of vertigo in an Asian population-based cohort.. Commun Biol. 7(1):1034., 7(1):1034. (2024-08) [JCR] [WOS]
  3. AM Lim, EU Lim, PL Chen, CS Fann* Unsupervised Clustering Identified Clinically Relevant Metabolic Syndrome Endophenotypes in UK and Taiwan Biobanks. iScience (2024-05) [JCR] [WOS]
  4. Cheng YW, Liao YC, Chen CH, Chung CP, Fann CSJ, Chang CC, Lee YC, Tang SC. Contribution of the APOE Genotype to Cognitive Impairment in Individuals With NOTCH3 Cysteine-Altering Variants.. Journal of the American Heart Association e032689, e032689 (2023-11) [JCR] [WOS]
  5. Lee CT, Tsai WH, Chang CC, Chen PC, Fann CS, Chang HK, Liu SY, Wu MZ, Chiu PC, Hsu WM, Yang WS, Lai LP, Tsai WY, Yang SB, Chen PL. Genotype-phenotype correlation in Taiwanese children with diazoxide-unresponsive congenital hyperinsulinism.. Frontiers in Endocrinology 14:1283907., 14:1283907. (2023-11) [JCR] [WOS]
  6. Winsvold BS, Harder AVE, Ran C, Chalmer MA, Dalmasso MC, Ferkingstad E, Tripathi KP, Bacchelli E, Børte S, Fourier C, Petersen AS, Vijfhuizen LS, Magnusson SH, O\'Connor E, Bjornsdottir G, Häppölä P, Wang YF, Callesen I, Kelderman T, Gallardo VJ, de Boer I, Olofsgård FJ, Heinze K, Lund N, Thomas LF, Hsu CL, Pirinen M, Hautakangas H, Ribasés M, Guerzoni S, Sivakumar P, Yip J, Heinze A, Küçükali F, Ostrowski SR, Pedersen OB, Kristoffersen ES, Martinsen AE, Artigas MS, Lagrata S, Cainazzo MM, Adebimpe J, Quinn O, Göbel C, Cirkel A, Volk AE, Heilmann-Heimbach S, Skogholt AH, Gabrielsen ME, Wilbrink LA, Danno D, Mehta D, Guðbjartsson DF; HUNT All-In Headache, The International Headache Genetics Consortium, DBDS Genomic Consortium; Rosendaal FR, Willems van Dijk K, Fronczek R, Wagner M, Scherer M, Göbel H, Sleegers K, Sveinsson OA, Pani L, Zoli M, Ramos-Quiroga JA, Dardiotis E, Steinberg A, Riedel-Heller S, Sjöstrand C, Thorgeirsson TE, Stefansson H, Southgate L, Trembath RC, Vandrovcova J, Noordam R, Paemeleire K, Stefansson K, Fann CS, Waldenlind E, Tronvik E, Jensen RH, Chen SP, Houlden H, Terwindt GM, Kubisch C, Maestrini E, Vikelis M, Pozo-Rosich P, Belin AC, Manjit Matharu, Arn M J M van den Maagdenberg, Thomas F Hansen, Alfredo Ramirez, John-Anker Zwart; International Consortium for Cluster Headache Genetics. Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor.. Annals of Neurology 2023-07, 07-24 (2023-07) [JCR] [WOS]
  7. Chen TH, Hsu HC, You JF, Lai CC, Tsou YK, Hsu CL, Fann CSJ, Chien RN, Chang ML. Extracellular Nicotinamide Phosphoribosyltransferase as a Surrogate Marker of Prominent Malignant Potential in Colonic Polyps: A 2-Year Prospective Study.. Cancers. 15(6):1702., 1702-1702 (2023-03) [JCR] [WOS]
  8. Lian IB, Sie JJ, Chang CC, Fann CSJ, Huang CH. Effects of insomnia and non-vasomotor menopausal symptoms on coronary heart disease risk: a mendelian randomization study.. Heliyon. 9(2):e13569, e13569-e13569 (2023-02) [JCR] [WOS]
  9. Chen SP, Hsu CL, Wang YF, Yang FC, Chen TH, Huang JH, Pan LH, Fuh JL, Chang HC, Lee YL, Chang HC, Lee KH, Chang YC, Fann CS*, Wang SJ. Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan.. J Headache Pain. 23(1), 147 (2022-11-21) [JCR] [WOS]
  10. Lee CJ, Chen TH, Lim AMW, Chang CC, Sie JJ, Chen PL, Chang SW, Wu SJ, Hsu CL, Hsieh AR, Yang WS, Fann CSJ* Phenome-wide analysis of Taiwan Biobank reveals novel glycemia-related loci and genetic risks for diabetes. Commun Biol. 5(1), 1175 (2022-11-03) [JCR] [WOS]

- POSTDOC -
SIE, JIA-JYUN
SIE, JIA-JYUN
LO, YEN-LI
LO, YEN-LI
- RESEARCH ASSOCIATES -
Chang, Chien-Ching
Chang, Chien-Ching
Hsu	, Chia-Lin
Hsu , Chia-Lin
Wu, Shang-Jung
Wu, Shang-Jung
- VISITOR -
Chen, Ting-Huei
Chen, Ting-Huei
- ALUMNI -
Lee, CJ
Lee, CJ
LIM, Aylwin Ming Wee
LIM, Aylwin Ming Wee