Division of Biostatistics, Department of Preventive Medicine and Environmental Health,
Ph.D. University of Iowa, Iowa City, Iowa, US
Dr. Cathy S.J. Fann specializes in genetic epidemiology and biostatistics, leveraging biobank data, machine learning, and statistical genetics to advance precision medicine. Her research spans neurological, psychiatric, and respiratory diseases, focusing on migraine, Alzheimer's, schizophrenia, and asthma.
Key Findings:
* Migraine, Cluster Headache and Vertigo: Identified novel genetic risk loci through GWAS and bioinformatic tools in Han Chinese populations.
* Alzheimer's Disease: Developed refined risk models incorporating APOE ε4 allele and PM2.5 exposure.
* Polygenic Risk Scores (PRS): Improved disease risk prediction and treatment stratification.
Current Projects:
1. Asthma Subtypes: Using AI to classify phenotypic and genetic clusters for personalized treatment.
2. Taiwan Precision Medicine Initiative: Enhancing PRS applications in clinical practice.
3. Chronic Migraine Research: Multi-omics integration to identify novel therapeutic targets.
Research Highlights:
* Developed statistical techniques for rare variant analysis and synthetic haplotype generation.
* Contributed to genetic screening policies and public health initiatives.
* Advocate for Open Science and genomic data sharing.
Selected Publications:
1. Lim AM et al. (2024). Metabolic Syndrome Endophenotypes in UK and Taiwan Biobanks. iScience. DOI: 10.1016/j.isci.2024.109815
2. Chen SP et al. (2024). GWAS Identifies Novel Loci for Vertigo. Communications Biology.
3. Cheng YW et al. (2023). APOE Genotype & Cognitive Impairment. J Am Heart Assoc.
4. Winsvold BS et al. (2023). Cluster Headache GWAS Identifies Eight Loci. Ann Neurol.
5. Lee CJ et al. (2022). Taiwan Biobank Analysis on Glycemia-related Loci. Communications Biology.
For a full list, visit ORCID profile