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Dr. Ko, Tai-Ming

Joint Appointment Assistant Research Fellow
  • 02-26523592 (Lab) (Room No: N802)
  • 02-26523591 (Office)
  • 03-5712121#59731 (NCTU)
  • 02-26523593 (Fax)




Genomic medicine

Education and Positions:
  • B.S. National Taiwan University

    M.S. National Cheng Kung University

    Ph.D. National Taiwan University

    Postdoc. Academia Sinica

    Postdoc. University of Chicago, Chicago, IL

Our research interests are in applying advanced genomic platform to find the solution for improving the population health. We currently aim at translating the promise of high-throughput genomic medicine into clinical reality. We mainly apply single-cell multi-omics approaches and the developing technologies for analyzing highly polymorphic gene (i.e. HLA, TCR, KIR). In addition, our lab also has early access to the newest single-cell multi-omics technologies (scRNA-seq, scATAC-seq, scDNA-seq, CITE-seq, scVDJ-seq, spatial profiling, and other advanced single-cell platforms). Based on these platforms, we currently focus on leveraging single-cell analysis for translational studies in immune-mediated diseases and immunotherapies.

Journal 17 Book 0

  1. Huang LW, Wei JC, Chen DY, Chen YJ, Tang KT, Ko TM, Chen HH Bidirectional association between systemic lupus erythematosus and macrophage activation syndrome: a nationwide population-based study. Rheumatology (Oxford, England) 61(3), 1123-1132 (2022) [JCR] [WOS]
  2. Chang CL, Lin MC, Lin CH, Ko TM Maternal and Perinatal Factors Associated With Kawasaki Disease Among Offspring in Taiwan. JAMA network open 4(3), e213233 (2021) [JCR] [WOS]
  3. Huang WC, Huang HT, Chen PY, Wang WC, Ko TM, Shrestha S, Yang CD, Tai CS, Chiew MY, Chou YP, Hu YF, Huang HD SVAD: A genetic database curates non-ischemic sudden cardiac death-associated variants. PloS one 15(8), e0237731 (2020) [JCR] [WOS]
  4. Ko TM, Chang JS, Chen SP, Liu YM, Chang CJ, Tsai FJ, Lee YC, Chen CH, Chen YT, Wu JY Genome-wide transcriptome analysis to further understand neutrophil activation and lncRNA transcript profiles in Kawasaki disease. Scientific reports 9(1), 328 (2019) [JCR] [WOS]
  5. Ko TM, Kiyotani K, Chang JS, Park JH, Yin Yew P, Chen YT, Wu JY, Nakamura Y Immunoglobulin profiling identifies unique signatures in patients with Kawasaki disease during intravenous immunoglobulin treatment. Human molecular genetics 27(15), 2671-2677 (2018) [JCR] [WOS]
  6. Lee TH, Ko TM, Chen CH, Chang YJ, Lu LS, Chang CH, Huang KL, Chang TY, Lee JD, Chang KC, Yang JT, Wen MS, Wang CY, Chen YT, Chen TC, Chou SY, Lee MM, Chen YT, Wu JY A genome-wide association study links small-vessel ischemic stroke to autophagy. Scientific reports 7(1), 15229 (2017) [JCR] [WOS]
  7. Lee TH, Ko TM, Chen CH, Lee MT, Chang YJ, Chang CH, Huang KL, Chang TY, Lee JD, Chang KC, Yang JT, Wen MS, Wang CY, Chen YT, Hsieh CS, Chou SY, Liu YM, Chen HW, Liao HT, Wang CW, Chen SP, Lu LS, Chen YT, Wu JY Identification of PTCSC3 as a Novel Locus for Large-Vessel Ischemic Stroke: A Genome-Wide Association Study. Journal of the American Heart Association 5(3), e003003 (2016) [JCR] [WOS]
  8. Ko TM, Wong CS, Wu JY, Chen YT Pharmacogenomics for personalized pain medicine. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 54(1), 24-30 (2016) [JCR] [WOS]
  9. Ko TM, Kuo HC, Chang JS, Chen SP, Liu YM, Chen HW, Tsai FJ, Lee YC, Chen CH, Wu JY, Chen YT CXCL10/IP-10 is a biomarker and mediator for Kawasaki disease. Circulation research 116(5), 876-83 (2015) [JCR] [WOS]
  10. Lin CH, Chen JK, Ko TM, Wei CY, Wu JY, Chung WH, Chen SY, Liao YD, Hung SI, Chen YT Immunologic basis for allopurinol-induced severe cutaneous adverse reactions: HLA-B*58:01-restricted activation of drug-specific T cells and molecular interaction. The Journal of allergy and clinical immunology 135(4), 1063-1065.e5 (2015) [JCR] [WOS]