Dr. Chen, Shih-Yu 's publons link picture

Dr. Chen, Shih-Yu

Assistant Research Fellow
  • 2652-3589 (Lab) (Room No: N621)
  • 2652-3994 (Office)

Specialty:
  • Single cell analysis

Education and Positions:
  • M.D. National Taiwan University

    Ph.D. University of California, Davis

    Research Scientist. Stanford University


The ability to detect and quantify more types of biomolecules at higher resolutions is crucial for our understanding of biological functions in cells and tissues. For example, single-cell level analyses by fluorescence-based flow cytometry have been a mainstay of immunologic inquiry for nearly four decades. Flow cytometry, which can provide data on ploidy, immuno-phenotype, frequency of cell subsets, expression levels of proteins, and function in single cells, has revolutionized our understanding of cellular individuality in immune function. Our laboratory uses two recently developed technologies, mass cytometry and multiplexed ion beam imaging (MIBI), which facilitate high dimensional (up to 50 parameters), quantitative analysis of molecules at single-cell resolution to enable a deeper understanding of how the immune system interacts with cancer cells. Better understand the underlying mechanism of the dysregulations of immune cells within tumor microenvironment could potentially lead to the design of therapeutic strategies to enhance or reinvigorate the anti-tumor effector functions. 

  1. Chung Kuei-Pin, Su Jia-Ying, Wang Yi-Fu, Budiarto Bugi Ratno, Yeh Yu-Chang, Cheng Jui-Chen, Keng Li-Ta, Chen Yi-Jung, Lu Ya-Ting, Juan Yi-Hsiu, Nakahira Kiichi, Ruan Sheng-Yuan, Chien Jung-Yien, Chang Hou-Tai, Jerng Jih-Shuin, Huang Yen-Tsung, (Chen Shih-Yu)*, Yu Chong-Jen* Immunometabolic features of natural killer cells are associated with infection outcomes in critical illness Frontiers in Immunology 15, 1334882 (2024-02) [JCR] [WOS]
  2. Siew Jian Jing, Chen Hui-Mei, Chiu Feng-Lan, Lee Chia-Wei, Chang Yao-Ming, Chen Hung-Lin, Nguyen Thi Ngoc Anh, Liao Hung-Ting, Liu Mengyu, Hagar Hsiao-Tien, Sun Yung-Chen, Lai Hsing-Lin, Kuo Min-Hao, Blum David, Buée Luc, Jin Lee-Way, (Chen Shih-Yu), Ko Tai-Ming, Huang Jie-Rong, Kuo Hung-Chih, Liu Fu-Tong, Chern Yijuang Galectin-3 aggravates microglial activation and tau transmission in tauopathy Journal of Clinical Investigation 134(2), e165523 (2024-01) [JCR] [WOS]
  3. Hong Shiao-Ya, Lu Ya-Ting, Chen Shih-Yu, Hsu Chiung-Fang, Lu Yi-Chun, Wang Cheng-Yi, Huang Kun-Lun Targeting pathogenic macrophages by the application of SHP-1 agonists reduces inflammation and alleviates pulmonary fibrosis Cell Death & Disease 14(6), 352 (2023-06-08) [JCR] [WOS]
  4. Cui Lu, Fang Zhuoqing, De Souza Cristabelle Madona, Lerbs Tristan, Guan Yuan, Li Irene, Charu Vivek, Chen Shih-Yu, Weissman Irving, Wernig Gerlinde Innate immune cell activation causes lung fibrosis in a humanized model of long COVID Proceedings of the National Academy of Sciences 120(10), e2217199120 (2023-02-27) [JCR] [WOS]
  5. Huang Hsiang‐Chi, Wang Shih‐Han, Fang Guo‐Chen, Chou Wen‐Cheng, Liao Chun‐Che, Sun Cheng‐Pu, Jan Jia‐Tsrong, Ma Hsiu‐Hua, Ko Hui‐Ying, Ko Yi‐An, Chiang Ming‐Tsai, Liang Jian‐Jong, Kuo Chun‐Tse, Lee Te‐An, Morales‐Scheihing Diego, Shen Chen‐Yang, Chen Shih‐Yu, McCullough Louise D., Cui Lu, Wernig Gerlinde, Tao Mi‐Hua, Lin Yi‐Ling, Chang Yao‐Ming, Wang Shu‐Ping, Lai Yun‐Ju, Li Chia‐Wei Upregulation of PD‐L1 by SARS‐CoV‐2 promotes immune evasion Journal of Medical Virology 95(2), e28478 (2023-01-07) [JCR] [WOS]
  6. Hsieh Wan-Chen, Budiarto Bugi Ratno, Wang Yi-Fu, Lin Chih-Yu, Gwo Mao-Chun, So Dorothy Kazuno, Tzeng Yi-Shiuan, Chen Shih-Yu Spatial multi-omics analyses of the tumor immune microenvironment Journal of Biomedical Science 29(1), 96 (2022-11-14) [JCR] [WOS]
  7. Thio Christina Li-Ping, Lai Alan Chuan-Ying, Wang Jo-Chiao, Chi Po-Yu, Chang Ya-Lin, Ting Yu-Tse, Chen Shih-Yu, Chang Ya-Jen Identification of a PD-L1+Tim-1+ iNKT subset that protects against fine particulate matter–induced airway inflammation JCI Insight 7(23), e164157 (2022) [JCR] [WOS]
  8. Coskun Ahmet F., Han Guojun, Ganesh Shambavi, Chen Shih-Yu, Clavé Xavier Rovira, Harmsen Stefan, Jiang Sizun, Schürch Christian M., Bai Yunhao, Hitzman Chuck, Nolan Garry P. Nanoscopic subcellular imaging enabled by ion beam tomography Nature Communications 12(1), 789 (2021-02) [JCR] [WOS]
  9. Guan Y, Enejder A, Wang M, Fang Z, Cui L, (Chen SY), Wang J, Tan Y, Wu M, Chen X, Johansson PK, Osman I, Kunimoto K, Russo P, Heilshorn SC, Peltz G A human multi-lineage hepatic organoid model for liver fibrosis. Nature communications 12(1), 6138 (2021) [JCR] [WOS]
  10. Weng Rueyhung R., Lu Hsuan-Hsuan, Lin Chien-Ting, Fan Chia-Chi, Lin Rong-Shan, Huang Tai-Chung, Lin Shu-Yung, Huang Yi-Jhen, Juan Yi-Hsiu, Wu Yi-Chieh, Hung Zheng-Ci, Liu Chi, Lin Xuan-Hui, Hsieh Wan-Chen, Chiu Tzu-Yuan, Liao Jung-Chi, Chiu Yen-Ling, Chen Shih-Yu, Yu Chong-Jen, Tsai Hsing-Chen Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer Nature Communications 12(1), 2163 (2021) [JCR] [WOS]

- POSTDOC -
Wang, Yi-Fu
Wang, Yi-Fu
- RESEARCH ASSOCIATES -
Lu, Ya-Ting
Lu, Ya-Ting
Yen, Chia-Chien
Yen, Chia-Chien
- STUDENTS -
Hsieh, Wan-Chen
Hsieh, Wan-Chen
Budiarto, Bugi Ratno
Budiarto, Bugi Ratno
Wang, Yi-Chuan
Wang, Yi-Chuan
- ALUMNI -
Hsiao, Hao-Wen
Hsiao, Hao-Wen