1992/12, PhD, University of California, Los Angeles (UCLA), USA
2014/7-2018/9, Deputy Director, IBMS, AS, Taipei, Taiwan
2020/9-2024/8, CEO, Emerging Infectious Disease Division (EIDD), Biomedical Translation Research Center (BioTReC), AS, Taipei, Taiwan
Dengue is one of the most important arboviral diseases caused by infection of four serotypes of dengue virus (DEN). We found that activation of interferon regulatory factor 3 (IRF3) triggered by viral infection and by foreign DNA and RNA stimulation was blocked by DEN-encoded NS2B3 through a protease-dependent mechanism.