Dr. Chang, Chen

Emeritus Research Fellow

  • Functional MRI/S
  • Neuroscience

Education and Positions:
  • Ph.D. University of Alabama at Birmingham

Highlight Detail

Negative cerebral blood volume fMRI response coupled with Ca2+-dependent brain activity in a dopaminergic road map of nociception.

Dr. Chang, Chen
Neuroimage, Dec 22, 2013

Decreased cerebral blood volume/flow (CBV/CBF) contributes to negative blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) signals. But it is still strongly debated whether these negative BOLD or CBV/CBF signals are indicative of decreased or increased neuronal activity. The fidelity of Ca2+ signals in reflecting neuronal excitation is well documented.