Dr. Huang, Tai-huang

Emeritus Research Fellow
  • 886-2-2789-9111(退休人員服務專線)

  • Structural Biology
  • Nuclear Magnetic Resonance Spectroscopy
  • Biophysics

Education and Positions:
  • Ph.D. Brandeis University

Highlight Detail

Structural dynamics of the two-component response regulator RstA in recognition of promoter DNA element.

Dr. Huang, Tai-huang
Nucleic Acids Res., Jul 02, 2014

The RstA/RstB system is a bacterial two-component regulatory system consisting of the membrane sensor, RstB and its cognate response regulator (RR) RstA. The RstA of Klebsiella pneumoniae (kpRstA) consists of an N-terminal receiver domain (RD, residues 1-119) and a C-terminal DNA-binding domain (DBD, residues 130-236). Phosphorylation of kpRstA induces dimerization, which allows two kpRstA DBDs to bind to a tandem repeat, called the RstA box, and regulate the expression of downstream genes.