Dr. Lim, Carmay 's orcid link picture Dr. Lim, Carmay 's publons link picture

Dr. Lim, Carmay

Distinguished Research Fellow
  • +886-2-2789-9043 (Lab) (Room No: N117)
  • +886-2-2652-3031 (Office)
  • +886-2-2788-7641 (Fax)

  • Computational Biophysics
  • Computational Chemistry
  • Bioinformatics

Education and Positions:
  • 1984, Ph.D. in Chemical Physics, University of Minnesota, Minneapolis

    1979, B.S. in Chemistry, Royal Holloway College, London University


Highlight Detail

Protein/solvent medium effects on Mg(2+)-carboxylate interactions in metalloenzymes.

Dr. Lim, Carmay
J Am Chem Soc, May 12, 2010

We employed umbrella sampling molecular dynamics simulations in explicit water to study the binding of the Mg(2+) cofactor to ribonuclease H (RNase H) from three different organisms. We show that the enzyme can differentiate between different Mg(2+)-binding modes that are nearly equally stable by creating a free-energy barrier between