Dr. Shieh, Sheau-Yann 's publons link picture

Dr. Shieh, Sheau-Yann

Research Fellow
  • 02-26523916 (Lab) (Room No: N347)
  • 02-27829143 (Fax)

  • Cancer Cell Biology
  • Cell Cycle Signaling

Education and Positions:
  • Ph.D. Baylor College of Medicine Post-doc:Columbia University

Highlight Detail

p53-Mediated transactivation of LIMK2b links actin dynamics to cell cycle checkpoint control.

Dr. Shieh, Sheau-Yann
Oncogene, Mar 01, 2010

The p53 tumor suppressor protein is widely known for its role as a sequence-specific transcription factor that regulates the expression of stress response genes. Here, we report the identification of LIMK2, which encodes a kinase that regulates actin dynamics through phosphorylation of cofilin, as a p53 target upregulated by DNA damage.