Dr. Su, Tsann-Long

Emeritus Research Fellow

  • Medicinal Chemistry
  • Organic Chemistry
  • Phytochemistry

Education and Positions:
  • Ph.D. Free University of Berlin, Germany

Highlight Detail

Novel antitumor indolizino[6,7-b]indoles with multiple modes of action: DNA cross-linking and topoisomerase I and II inhibition.

Dr. Su, Tsann-Long
J Med Chem., Jan 29, 2013

A series of bis(hydroxymethyl)indolizino[6,7-b]indoles and their bis(alkylcarbamates) were synthesized for antitumor studies. These agents were designed as hybrid molecules of β-carboline (topoisomerase inhibition moiety) and bis(hydroxymethyl)pyrrole (DNA cross-linking moiety). The preliminary antitumor studies indicated that these agents exhibited significant cytotoxicity against a variety of human tumor cells in vitro.