Dr. Shih, Chiaho 's publons link picture

Dr. Shih, Chiaho

Emeritus Research Fellow

  • Molecular Biology
  • Viral Hepatitis and Hepatoma
  • Cancer

Education and Positions:
  • Ph.D. Massachusetts Institute of Technology

Highlight Detail

Control and Eradication Strategies of Hepatitis B Virus

Dr. Shih, Chiaho
Trends in Microbiology, Jun 07, 2016

Hepatitis B virus (HBV) is a major human pathogen, and chronic hepatitis can lead to cirrhosis and malignant hepatocellular carcinoma. While HBV vaccine and treatment are available, it has remained a challenge to completely eradicate the virus from patients. Current therapy using either interferon or polymerase inhibitors cannot cure HBV with a high efficacy. Lifelong therapy is needed to suppress HBV in patients who achieve no seroconversion. Here, we review recent exciting advances of new strategies, including the inhibition of viral entry, the destruction or silencing of HBV covalently closed circular DNA (cccDNA), and breaking immune tolerance. Combinations of different therapeutic strategies could improve the cure rate of viral persistence in chronic hepatitis B.