Dr. Kannagi, Reiji 's publons link picture

Dr. Kannagi, Reiji

Emeritus Research Fellow

  • Cancer-associated Glycans
  • Lymphocyte Homing
  • Selectins, Siglecs and CD44 

Education and Positions:
  • M.D., Ph.D. Kyoto University

Highlight Detail

Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial–mesenchymal transition

Dr. Kannagi, Reiji
PNAS, May 15, 2012

Sialyl Lewis x (sLex) and sialyl Lewis a (sLea)   glycans are expressed on highly metastatic colon cancer cells. They   promote extravasation of cancer cells and tumor angiogenesis                       via interacting with E-selectin on endothelial   cells. Recently, epithelial–mesenchymal transition (EMT) has been noted   as                       a critical phenotypic alteration in metastatic   cancer cells.