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Dr. Cheng, Yang

Assistant Research Fellow
  • 2789-9097 (Lab) (Room No: N401)
  • 2652-3966 (Office)

  • Human T cell biology, virus-specific memory T cells
  • Highly multiplexed combinatorial pMHC tetramer staining
  • Single-cell multi-omics
  • T cell receptor
  • High-dimensional analysis

Education and Positions:
  • M.Sc., University College London
    Ph.D., Nanyang Technological University – A*STAR joint program
    Postdoc Fellow, Singapore Immunology Network, A*STAR
    Senior Research Scientist, Massachusetts General Hospital, Harvard Medical School

Dr. Cheng, Yang 's

Journal 19 Book 0

  1. (Cheng Y) and Newell EW* Deep Profiling Human T Cell Heterogeneity by Mass Cytometry. ADVANCES IN IMMUNOLOGY 131, 104-134 (2016) [JCR] [WOS]
  2. Boettler T, Schneider D, (Cheng Y), Kadoya K, Brandon EP, Martinson L, von Herrath M* Pancreatic Tissue Transplanted in TheraCyte Encapsulation Devices Is Protected and Prevents Hyperglycemia in a Mouse Model of Immune-Mediated Diabetes. CELL TRANSPLANTATION 25(3), 609-614 (2016) [JCR] [WOS]
  3. Van Belle TL, Pagni PP, Liao J, Sachithanantham S, Dave A, Bel Hani A, Manenkova Y, Amirian N, (Cheng Y), Morin B, Zhang H, Campbell IL, von Herrath MG* Beta-cell specific production of IL6 in conjunction with a mainly intracellular but not mainly surface viral protein causes diabetes. JOURNAL OF AUTOIMMUNITY 55, 24-32 (2014-12) [JCR] [WOS]
  4. Boettler T, Choi YS, Salek-Ardakani S, (Cheng Y), Moeckel F, Croft M, Crotty S, von Herrath M* Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1. JOURNAL OF IMMUNOLOGY 191(10), 5026-5035 (2013-11-15) [JCR] [WOS]
  5. Boettler T, Pagni PP, Jaffe R, (Cheng Y), Zerhouni P, von Herrath M* The clinical and immunological significance of GAD-specific autoantibody and T-cell responses in type 1 diabetes. JOURNAL OF AUTOIMMUNITY 44, 40-48 (2013-08) [JCR] [WOS]
  6. Boettler T, Moeckel F, (Cheng Y), Heeg M, Salek-Ardakani S, Crotty S, Croft M, von Herrath MG* OX40 facilitates control of a persistent virus infection. PLOS PATHOGENS 8(9), e1002913 (2012-09) [JCR] [WOS]
  7. Fousteri G, Jasinski J, Dave A, Nakayama M, Pagni P, Lambolez F, Juntti T, Sarikonda G, (Cheng Y), Croft M, Cheroutre H, Eisenbarth G, von Herrath M* Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice. DIABETES 61(5), 1169-79 (2012) [JCR] [WOS]
  8. Boettler T, (Cheng Y), Ehrhardt K, von Herrath M* TGF-beta blockade does not improve control of an established persistent viral infection. VIRAL IMMUNOLOGY 25(3), 232-8 (2012) [JCR] [WOS]
  9. Nebbia G, Peppa D, Schurich A, Khanna P, Singh HD, (Cheng Y), Rosenberg W, Dusheiko G, Gilson R, ChinAleong J, Kennedy P, Maini MK* Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. PLOS ONE 7(10), e47648 (2012) [JCR] [WOS]