Ph.D. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota
Wrestling with SUMO and other protein modifications
SUMO modification is emerging as an important post-translational control of cellular events. While many SUMO-modified transcription factors and coactivators have been identified, little is known about the mechanism underlying SUMO-elicited protein-protein interaction and regulation. In past few years, my lab has focused on the moelcular mechanisms of Daxx protein in transcriptional control and sumoylation via a SUMO-interacting motif. We further investigate protein phosphorylation, acetylation and other modifications controlling protein sumoylation. In addition, we have recently identified several SUMO-modified factors associated with signal transduction, cell cycle, cell mobility, and viral infection. Studies are undergoing to dissect the functional significances of these factors in SUMO modification and explore the underlying mechanisms as to how cells modulate the levels of sumoylated factors in response to distinct intracellular milieu.