Dr. Chen, Joanne Jeou-Yuan 張久瑗 博士

PUBLICATIONS 研究論文

• 1.	Guo JY, Chiu CH, Wang MJ, Li FA, and Chen JY* Proteoglycan serglycin promotes non-small cell lung cancer cell migration through the interaction of its glycosaminoglycans with CD44 J Biomedical Sciences 27(1) (2020-01) [JCR] [WOS]

• 2.	Guo JY, Hsu HS, Tyan SW, Li FY, Shew JY, Lee WH, (Chen JY)* Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner ONCOGENE 36, 2457-2471 (2017-04) [JCR] [WOS]

• 3.	Yao NW, Chang C, Lin HT, Yen CT*, Chen JY*. Functional assessment of glioma pathogenesis by in vivo multi-parametric magnetic resonance imaging and in vitro analyses. Scientific Reports 6, 26050-26061 (2016-05) [JCR] [WOS]

• 4.	Wang YW, Ma X, Zhang YA, Wang MJ, Yatabe Y, Lam S, Girard L, Chen JY*, Gazdar AF* (*, equal contribution) ITPKA gene body methylation regulates gene expression and serves as an early diagnostic marker in lung and other cancers. JOURNAL OF THORACIC ONCOLOGY 11, 1469-1481 (2016) [JCR] [WOS]

• 5.	Sudhir PR, Lin ST, Chia-Wen C, Yang SH, Li AF, Lai RH, Wang MJ, Chen YT, Chen CF, Jou YS, Chen JY* Loss of PTPRM associates with the pathogenic development of colorectal adenoma-carcinoma sequence. Scientific Reports 5, 9633-9641 (2015) [JCR] [WOS]

• 6.	Chen CC, Hsu YH, Jayaseema DM, Chen JY, Hueng DY, Chang C White matter tracts for the trafficking of neural progenitor cells characterized by cellular MRI and immunohistology: the role of CXCL12/CXCR4 signaling. Brain structure & function 220(4), 2073-2085 (2015) [JCR] [WOS]

• 7.	Tiong KL, Chang KC, Yeh KT, Liu TY, Wu JH, Hsieh PH, Lin SH, Lai WY, Hsu YC, Chen JY, Chang JG, Shieh GS CSNK1E/CTNNB1 are synthetic lethal to TP53 in colorectal cancer and are markers for prognosis. Neoplasia 16(5), 441-450 (2014) [JCR] [WOS]

• 8.	Sudhir PR, Chen JY. Functional Phosphoproteomics of Oncogenic KRAS Signaling Ras Signaling: Methods and protocols 157-166 (2014) [JCR] [WOS]

• 9.	Sudhir PR, Chen JY Functional phosphoproteomics of oncogenic KRAS signaling. Methods in molecular biology (Clifton, N.J.) 1120, 157-166 (2014) [JCR] [WOS]

• 10.	Lin, H.-Y., Lai, R.-H., Lin, S.-T., Lin, R.-C., Wang, M.-J., Lin, C.-C., Wang, F.-F., and Chen, J.-Y. Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation to mitochondria Cell Death & Differentiation 20(1), 139-153 (2013-01) [JCR] [WOS]

• 11.	Sudhir PR, Chen CH, Pavana Kumari M, Wang MJ, Tsou CC, Sung TY, Chen JY, Chen CH Label-free quantitative proteomics and N-glycoproteomics analysis of KRAS-activated human bronchial epithelial cells. Molecular & cellular proteomics : MCP 11(10), 901-915 (2012) [JCR] [WOS]

• 12.	Sudhir, P.-R., Hsu, C.-L., Wang, Y.-T., Chen, Y.-J., Sung, T.-Y., Hsu, W.-L., Yang, U.-C., and Chen, J.-Y. Phosphoproteomics identifies oncogenic Ras signaling targets and their involvement in lung adenocarcinomas. PLoS One 6(5), e20199 (2011-05) [JCR] [WOS]

• 13.	ANNA FEN-YAU LI, HAN-SHUI HSU, CHIH-YI HSU, ALICE CHIA-HENG LI, JEOU-YUAN CHEN A 20-year Retrospective Study of Small-Cell Carcinomas in Taiwan Journal of Surgical Oncology 102(5), 497-502 (2010-06) [JCR] [WOS]

• 14.	Lai, R.-H., Hsiao, Y.-W., Wang, M.-J., Lin, H.-Y., Wu, C.-W., Chi, C.-W., Li, A. F.-Y., Jou, Y.-S., and \"Chen, J.-Y.*\" SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation. CANCER LETTERS 288(1), 75-85 (2010-02) [JCR] [WOS]

• 15.	Hsu FF, Lin TY, Chen JY, Shieh SY p53-Mediated transactivation of LIMK2b links actin dynamics to cell cycle checkpoint control. Oncogene 29(19), 2864-2876 (2010) [JCR] [WOS]

• 16.	Li AF, Li AC, Hsu CY, Li WY, Hsu HS, Chen JY Small cell carcinomas in gastrointestinal tract: immunohistochemical and clinicopathological features. Journal of clinical pathology 63(7), 620-625 (2010) [JCR] [WOS]

• 17.	Lai, R.-H., Wang, M.-J., Yang, S.-H., and \"Chen, J.-Y.*\" Genomic organization and functional characterization of the promoter for the human suppressor of cytokine signaling 6 gene GENE 448(1), 64-73 (2009-12) [JCR] [WOS]

• 18.	J.-L. Lee, M.-J. Wang, and \"J.-Y. Chen*\" Acetylation and activation of STAT3 mediated by nuclear translocation of CD44 JOURNAL OF CELL BIOLOGY 185, 949-957 (2009-06) [JCR] [WOS]

• 19.	A. F. Li, C. Y. Hsu, A. Li, L. C. Tai, W. Y. Liang, W. Y. Li, S. H. Tsay and J. Y. Chen A 35-year retrospective study of carcinoid tumors in Taiwan: differences in distrbution with a high probability of associated second primary malignancies Cancer 112(2), 274-283 (2008) [JCR] [WOS]

• 20.	A. F. Li, A. C. Li, S. H. Tsay, W. Y. Li, W. Y. Liang and J. Y. Chen Alterations in the p16INK4a/cyclin D1/RB pathway in gastrointestinal tract endocrine tumors Am J Clin Pathol 130(4), 535-542 (2008) [JCR] [WOS]

• 21.	J.-L. Lee, M.-J. Wang, P.-R. Sudhir and \"J.-Y. Chen*\" CD44 engagement promotes matrix-derived survival through the CD44-SRC-Integrin axis in lipid rafts Molecular and Cellular Biology 28, 5710-5723 (2008) [JCR] [WOS]

• 22.	C. F. Tsai, Y. T. Wang, Y. R. Chen, C. Y. Lai, P. Y. Lin, K. T. Pan, J. Y. Chen, K. H. Khoo and Y. J. Chen Immobilized metal affinity chromatography revisited: pH/acid control toward high selectivity in phosphoproteomics J Proteome Res 7(9), 4058-4069 (2008) [JCR] [WOS]

• 23.	Y. F. Wang, J. Y. Chen, S. Y. Chang, J. H. Chiu, W. Y. Li, P. Y. Chu, S. K. Tai1 and L. S. Wang Nm23-H1 expression of metastatic tumors in the lymph nodes is a prognostic indicator of oral squamous cell carcinoma Int. J. Cancer 122, 377-386 (2008) [JCR] [WOS]

• 24.	J.-H. Lin, C.-H. Tsai, J.-S. Chu, J.-Y. Chen, K. Takada and J.-Y. Shew Dysregulation of HER2/HER3 signaling axis in Epstein-Barr virus-infected breast carcinoma cells J. Virol 81, 5705-5713 (2007) [JCR] [WOS]

• 25.	J. L. Lee, M. J. Wang, P. R. Sudhir, G. D. Chen, C. W. Chi and J. Y. Chen Osteopontin promotes integrin activation through outside-in and inside-out mechanisms: OPN-CD44v interaction enhances survival in gastrointestinal cancer cells Cancer Res 67, 2089-2097 (2007) [JCR] [WOS]

• 26.	A. F. Li, S. H. Tsay, W. Y. Liang, W. Y. Li and J. Y. Chen Clinical significance of p16INK4a and p53 overespression in endocrine tumors of the gastrointestinal tract Am J Clin Pathol 126(6), 856-865 (2006) [JCR] [WOS]

• 27.

  Y. R. Chen, H. F. Juan, H. C. Huang, H. H. Huang, Y. J. Lee, M. Y. Liao, C. W. Tseng, L. L. Lin, J. Y. Chen, M. J. Wang, J. H. Chen and Y. J. Chen Quantitative Proteomic and Genomic Profiling Reveals Metastasis-Related Protein Expression Patterns in Gastric Cancer Cells J Proteome Res 5(10), 2727-2742 (2006) [JCR] [WOS]

• 28.

  G. D. Chen, C. M. Chou, S. P. Hwang, F. F. Wang, Y. C. Chen, C. C. Hung, J. Y. Chen and C. J. Huang Requirement of nuclear localization and transcriptional activity of p53 for its targeting to the yolk syncytial layer (YSL) nuclei in zebrafish embryo and its use for apoptosis assay Biochemical and Biophysical Research Communications 344(1), 272-282 (2006) [JCR] [WOS]

• 29.	H. J. Huang, T. C. Lee, R. N. Huang, J. Y. Chen and K. Peck Identification of p53-regulated genes in human cancer cells by genome-wide transcription profiling with cDNA microarray J Genet Mol Biol 16, 63-71 (2005) [JCR] [WOS]

• 30.

  H. S. Wu, Y. C. Hsieh, I. J. Su,T. H. Lin, S. C. Chiu, Y. F. Hsu, J. H. Lin, M. C. Wang, J. Y. Chen, P. W. Hsiao, G. D. Chang, A. H. Wang, H. W. Ting, C. M. Chou and C. J. Huang Early detection of antibodies against various structural proteins of the SARS-associated coronavirus in SARS patients J Biomed Sci 11, 117-126 (2004) [JCR] [WOS]

• 31.	C. F. Kao, S. Y. Chen, J. Y. Chen and Y. H. Wu Lee Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis C virus core protein Oncogene 23, 2472-2483 (2004) [JCR] [WOS]

• 32.	C. A. Liu, M. J. Wang, C. W. Chi, C. W. Wu and J. Y. Chen Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma J Biomed Sci 11, 661-670 (2004) [JCR] [WOS]

• 33.	C. A. Liu,M. J. Wang, C. W. Chi, C. W. Wu and J. Y. Chen Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis Oncogene 23, 8731-8742 (2004) [JCR] [WOS]

• 34.	S. C. Sue, J. Y. Chen and T. H. Huang Sequence specific 1H, 13C and 15N resonance assignments of the hath-domain of human hepatoma-derived growth factor J Biomol NMR 29, 95-96 (2004) [JCR] [WOS]

• 35.	S. C. Sue, J. Y. Chen, S. C. Lee, W. G. Wu and T. H. Huang Solution Structure and Heparin Interaction of Human Hepatoma-derived Growth Factor J Mol Biol 343, 1365-1377 (2004) [JCR] [WOS]

• 36.

  Y. C. Hsieh, M. S. Chang, J. Y. Chen, J. J. Yen, I. C. Lu, C. M. Chou and C. J. Huang Cloning of zebrafish BAD, a BH3-only proapoptotic protein, whose overexpression leads to apoptosis in COS-1 cells and zebrafish embryos Biochemical and Biophysical Research Communications 304, 667-675 (2003) [JCR] [WOS]

• 37.	C.S.J. Fann, J. Y. Chen, C. W. Wu and C. W. Chi Regarding Clinical Implications of Chromosomal Abnormalities in Gastric Adenocarcinomas Genes Chromosomes Cancer 38, 204-206 (2003) [JCR] [WOS]

• 38.	C. W. Wu, G. D. Chen, C. S. Fann, A. F. Lee, C. W. Chi, J. M. Liu, U. Weier and J. Y. Chen Clinical implications of chromosomal abnormalities in gastric adenocarcinomas Genes Chromosomes Cancer 35, 219-231 (2002) [JCR] [WOS]

• 39.	C. H. Huang, J. Y. Chen Identification of additional IE2-p86-responsive cis-repressive sequences within the human cytomegalovirus major immediate early gene promoter J Biomed Sci 9, 460-470 (2002) [JCR] [WOS]

• 40.	C. W. Wu, G. D. Chen, K. C. Jiang, A. F. Li, C. W. Chi, S. S. Lo and J. Y. Chen A genome-wide study of microsatellite instability in advanced gastric carcinoma Cancer 92, 92-101 (2001) [JCR] [WOS]

• 41.	L. S. Hsu, G. D. Chen, L. S. Lee, C. W. Chi, J. F. Cheng and J. Y. Chen Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity J Biol Chem 276, 31113-31123 (2001) [JCR] [WOS]

• 42.	P. K. Lo, J. Y. Chen, P. P. Tang, J. Lin, C. H. Lin, L. T. Su, C. H. Wu, T. L. Chen, Y. Yang and F. F. Wang Identification of a mouse thiamine transporter gene as a direct transcriptional target for p53 J Biol Chem 276, 37186-37193 (2001) [JCR] [WOS]

• 43.	P. K. Lo, J. Y. Chen, W. C. Lo, B. F. Chen, J. P. Hsin, P. P. Tang and F. F. Wang Identification of a novel mouse p53 target gene DDA3 Oncogene 18, 7765-7774 (1999) [JCR] [WOS]

• 44.	C. W. Wu, Y. Y. Lin, G. D. Chen, C. W. Chi, D. P. Carbone and J. Y. Chen Serum anti-p53 antibodies in gastric adenocarcinoma patients are associated with poor prognosis, lymph node metastasis and poorly differentiated nuclear grade British Journal of Cancer 80, 483-488 (1999) [JCR] [WOS]

• 45.	L. S. Hsu, A. P. Tsou, C. W. Chi, C. H. Lee and J. Y. Chen Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase J Biomed Sci 5, 141-149 (1998) [JCR] [WOS]

• 46.	C. H. Lee, L. S. Hsu, C. W. Chi, G. D. Chen, A. H. Yang and J. Y. Chen High frequency of rearrangement of the RET protooncogene (RET/PTC) in Chinese papillary thyroid carcinomas Journal of Clinical Endocrinology & Metabolism 83, 1629-1632 (1998) [JCR] [WOS]

• 47.	C. L. Lai, C. M. Tsai, T. T. Tsai, B. I. Kuo, K. T. Chang, H. T. Fu, R. P. Perng and J. Y. Chen Presence of serum anti-p53 antibodies is associated with pleural effusion and poor prognosis in lung cancer patients Clin Cancer Res 4, 3025-3030 (1998) [JCR] [WOS]

• 48.	Y. M. Chen, S. H. Chen, C. Y. Fu, J. Y. Chen and M. Osame Antibody reactivities to tumor-suppressor protein p53 and HTLV-I Tof, Rex and Tax in HTLV-I-infected people with differing clinical status Int J Cancer 71, 196-202 (1997) [JCR] [WOS]

• 49.	W. S. Chen, J. Y. Chen, J. M. Liu, W. C. Lin, K. L. King, J. Whang-Peng and W. K. Yang Microsatellite instability in sporadic-colon-cancer patients with and without liver metastases Int J Cancer 74, 470-474 (1997) [JCR] [WOS]

• 50.

  Y. Sekido, S. Bader, F. Latif, J Y. Chen, F. M. Duh, M. H. Wei, J. P. Albanesi, C. C. Lee, M. I. Lerman and J. D. Minna Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns Proceedings of the National Academy of Sciences of the United States of America 93, 4120-4125 (1996) [JCR] [WOS]