Dr. Kannagi, Reiji 神奈木玲兒 博士
M.D., Ph.D. Kyoto University
| 1. | Cai BH, Chao CF, Huang HC, Lee HY, Kannagi R, Chen JY Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation. International journal of molecular sciences 20(15) (2019-08) [JCR] [WOS] |
| 2. | Yeh YL, Wu WC, Kannagi R, Chiang BL, Liu FT, Lee YL Sialyl Glycan Expression on T Cell Subsets in Asthma: a correlation with disease severity and blood parameters. Scientific reports 9(1), 8947 (2019-06) [JCR] [WOS] |
| 3. | Huang HC, Chao CC, Wu PH, Chung HY, Lee HY, Suen CS, Hwang MJ, Cai BH, Kannagi R Epigenetic silencing of the synthesis of immunosuppressive Siglec ligand glycans by NF-κB/EZH2/YY1 axis in early-stage colon cancers Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1862(2), 173-183 (2019-02) [JCR] [WOS] |
| 4. | Cai BH, Wu PH, Chou CK, Huang HC, Chao CC, Chung HY, Lee HY, Chen JY, Kannagi R Synergistic activation of the NEU4 promoter by p73 and AP2 in colon cancer cells. Scientific reports 9(1), 950 (2019-01) [JCR] [WOS] |
| 5. | Lin YC, Liu CY, Kannagi R, Yang RB Inhibition of Endothelial SCUBE2 (Signal Peptide-CUB-EGF Domain-Containing Protein 2), a Novel VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) Coreceptor, Suppresses Tumor Angiogenesis. Arteriosclerosis, thrombosis, and vascular biology 38(5), 1202-1215 (2018-05) [JCR] [WOS] |
| 6. | Chang HC, Huang DY, Wu NL, Kannagi R, Wang LF, Lin WW BLIMP1 transcriptionally induced by EGFR activation and post-translationally regulated by proteasome and lysosome is involved in keratinocyte differentiation, migration and inflammation. Journal of dermatological science 92(2), 151-161 (2018) [JCR] [WOS] |
| 7. | Chen, J. Y., Huang, H. H., Yu, S. Y., Wu, S. J., Kannagi, R., and Khoo, K. H. Concerted mass spectrometry-based glycomic approach for precision mapping of sulfo sialylated N-glycans on human peripheral blood mononuclear cells and lymphocytes Glycobiology 28(1), 9-20 (2018) [JCR] [WOS] |
| 8. | Yu SY, Hsiao CT, Izawa M, Yusa A, Ishida H, Nakamura S, Yagi H, Kannagi R, Khoo KH Distinct substrate specificities of human GlcNAc-6-sulfotransferases revealed by mass spectrometry-based sulfoglycomic analysis. The Journal of biological chemistry 293(39), 15163-15177 (2018) [JCR] [WOS] |
| 9. | Kannagi R, Cai BH, Huang HC, Chao CC, Sakuma K Gangliosides and Tumors. Methods in molecular biology (Clifton, N.J.) 1804, 143-171 (2018) [JCR] [WOS] |
| 10. | Hebert, K. S., Seidman, D., Oki, A. T., Izac, J., Emani, S., Oliver, L. D., Jr., Miller, D. P., Tegels, B. K., Kannagi, R., Marconi, R. T., and Carlyon, J. A. Anaplasma marginale outer membrane protein A is an adhesin that recognizes sialylated and fucosylated glycans and functionally depends on an essential binding domain INFECTION AND IMMUNITY 85, e00968 (2017) [JCR] [WOS] |
| 11. | Chao, C. C., Wu, P. H., Huang, H. C., Chung, H. Y., Chou, Y. C., Cai, B. H., and Kannagi, R. Downregulation of miR-199a/b-5p is associated with GCNT2 induction upon epithelial-mesenchymal transition in colon cancer FEBS LETTERS 591, 1902-1917 (2017) [JCR] [WOS] |
| 12. | Lin, Y. C., Chao, T. Y., Yeh, C. T., Roffler, S. R., Kannagi, R., and Yang, R. B. Endothelial SCUBE2 interacts with VEGFR2 and regulates VEGF-Induced angiogenesis ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 37, 144-155 (2017) [JCR] [WOS] |
| 13. | Tu, C. F., Wu, M. Y., Lin, Y. C., Kannagi, R., and Yang, R. B. FUT8 promotes breast cancer cell invasiveness by remodeling TGF-beta receptor core fucosylation BREAST CANCER RESEARCH 19, 111 (2017) [JCR] [WOS] |
| 14. | Varki, A., Kannagi, R., Toole, B. P., and Stanley, P. Glycosylation changes in cancer Essentials of Glycobiology, 3rd Ed. 597-609 (2017) [JCR] [WOS] |
| 15. | Kannagi, R., Cai, B. H., Huang, H. C., and Sakuma, K. Regulation of cell surface glycan expression in cancer stem cells Cancer metastasis and cancer stem cell/niche 24-60 (2017) [JCR] [WOS] |
| 16. | Cai BH, Chao CF, Lin HC, Huang HY, Kannagi R, Chen JY A/T gap tolerance in the core sequence and flanking sequence requirements of non-canonical p53 response elements. Journal of biochemistry 159(6), 563-72 (2016) [JCR] [WOS] |
| 17. | Wu NL, Huang DY, Wang LF, Kannagi R, Fan YC, Lin WW Spleen Tyrosine Kinase Mediates EGFR Signaling to Regulate Keratinocyte Terminal Differentiation. The Journal of Investigative Dermatology 136, 192-201 (2016) [JCR] [WOS] |
| 18. | Tanaka, K., Tamiya-Koizumi, K., Yamada, M., Murate, T., Kannagi, R., and Kyogashima, M. Hypoxia remodels the composition of the constituent ceramide species of HexCer and Hex2Cer with phytosphingosine and hydroxy fatty acids in human colon cancer LS174T cells GLYCOCONJUGATE JOURNAL 32(8), 615-623 (2015-11) [JCR] [WOS] |
| 19. | Kannagi, R., Sakuma, K., Cai, B. H., and Yu, S. Y. Tumor-associated glycans and their functional roles in the multi-step process of human cancer progression Sugar Chains, Decoding the Functions of Glycans 139-158 (2015-01-07) [JCR] [WOS] |
| 20. | Yaji S, Manya H, Nakagawa N, Takematsu H, Endo T, Kannagi R, Yoshihara T, Asano M, Oka S Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTPbeta. Glycobiology 25(4), 376-385 (2015) [JCR] [WOS] |
| 21. | Kannagi, R., Kimura, N. Monoclonal antibodies for glycans as tools for identifying endogenous glycan ligands for human carbohydrate-recognition molecules Glycoscience: Biology and Medicine 1551-1556 (2015) [JCR] [WOS] |
| 22. | Miyara M, Chader D, Sage E, Sugiyama D, Nishikawa H, Bouvry D, Claer L, Hingorani R, Balderas R, Rohrer J, Warner N, Chapelier A, Valeyre D, Kannagi R, Sakaguchi S, Amoura Z, Gorochov G Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3high regulatory T cells in humans. Proceedings of the National Academy of Sciences of the United States of America 112(23), 7225-7230 (2015) [JCR] [WOS] |
| 23. | Kannagi, R., Sakuma, K., Ohmori, K. Sialyl sulfoglycans in immune regulation and their clinical applications Glycoscience: Biology and Medicine 559-571 (2015) [JCR] [WOS] |
| 24. | Macauley MS, Kawasaki N, Peng W, Wang SH, He Y, Arlian BM, McBride R, Kannagi R, Khoo KH, Paulson JC Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man. The Journal of biological chemistry 290(50), 30066-30077 (2015) [JCR] [WOS] |
| 25. | Kannagi, R. Fucosyltransferase 5. GDP-Fucose Lactosamine \\alpha 3/4-Fucosyltransferase (FUT5) Handbook of Glycosyltransferases and Related Genes, 2nd. Ed. 549-558 (2014) [JCR] [WOS] |
| 26. | Kannagi, R. Fucosyltransferase 6. GDP-Fucose Lactosamine alpha3-Fucosyltransferase (FUT6) Handbook of Glycosyltransferases and Related Genes, 2nd. Ed. 559-571 (2014) [JCR] [WOS] |
| 27. | Tanaka, K., Tamiya-Koizumi, K., Yamada, M., Murate, T., Kannagi, R., Kyogashima, M. Individual profiles of free ceramide species and the constituent ceramide species of sphingomyelin and neutral glycosphingolipid and their alteration according to the sequential changes of environmental oxygen content in human colorectal cancer Caco-2 cells GLYCOCONJUGATE JOURNAL 31(3), 209-219 (2014) [JCR] [WOS] |
| 28. | Crocker, P. R., Kannagi, R Introduction to special Issue Emerging Roles of Siglecs in Health and Disease GLYCOBIOLOGY 24(9), 784-784 (2014) [JCR] [WOS] |
| 29. | Kawamura YI, Adachi Y, Curiel DT, Kawashima R, Kannagi R, Nishimoto N, Dohi T Therapeutic adenoviral gene transfer of a glycosyltransferase for prevention of peritoneal dissemination and metastasis of gastric cancer CANCER GENE THERAPY 21(10), 427-433 (2014) [JCR] [WOS] |
| 30. | Kannagi, R., Sakuma, K., Ohmori, K. Cell-surface glycoconjugates controlling human T-lymphocyte homing: Implications for bronchial asthma and atopic dermatitis Chembiomolecular Science: At the Frontier of Chemistry and Biology 167-176 (2013) [JCR] [WOS] |
| 31. | Patnode, M. L., Yu, S. Y., Cheng, C. W., Ho, M. Y., Tegesjo, L., Sakuma, K., Uchimura, K., Khoo, K. H., Kannagi, R. , and Rosen, S. D. KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing GLYCOBIOLOGY 23(3), 381-394 (2013) [JCR] [WOS] |
| 32. | Miyazaki K, Sakuma K, Kawamura YI, Izawa M, Ohmori K, Mitsuki M, Yamaji T, Hashimoto Y, Suzuki A, Saito Y, Dohi T, Kannagi R Colonic epithelial cells express specific ligands for mucosal macrophage immunosuppressive receptors siglec-7 and -9 JOURNAL OF IMMUNOLOGY 188(9), 4690-4700 (2012) [JCR] [WOS] |
| 33. | Sakuma K, Chen GY, Aoki M, Kannagi R Induction of 6-sulfated glycans with cell adhesion activity via T-bet and GATA-3 in human helper T cells. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1820(7), 841-848 (2012) [JCR] [WOS] |
| 34. | Tanaka K, Tamiya-Koizumi K, Hagiwara K, Ito H, Takagi A, Kojima T, Suzuki M, Iwaki S, Fujii S, Nakamura M, Banno Y, Kannagi R, Tsurumi T, Kyogashima M, Murate T Role of down-regulated neutral ceramidase during all-trans retinoic acid-induced neuronal differentiation in SH-SY5Y neuroblastoma cells. Journal of Biochemistry 151(6), 611-620 (2012) [JCR] [WOS] |
| 35. | Sakuma K, Furuhashi T, Kondo S, Yabe U, Ohmori K, Ito H, Aoki M, Morita A, Kannagi R Sialic acid cyclization of human Th homing receptor glycan associated with recurrent exacerbations of atopic dermatitis JOURNAL OF DERMATOLOGICAL SCIENCE 68(3), 187-193 (2012) [JCR] [WOS] |
| 36. | Sakuma K, Aoki M, Kannagi R Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition. Proceedings of the National Academy of Sciences of the United States of America 109(20), 7776-77781 (2012) [JCR] [WOS] |
| 37. | Wang L, Kamijo Y, Matsumoto A, Nakajima T, Higuchi M, Kannagi R, Kyogashima M, Aoyama T, Hara A Kidney transplantation recovers the reduction level of serum sulfatide in ESRD patients via processes correlated to oxidative stress and platelet count. Glycoconjugate Journal 28(3-4), 125-135 (2011) [JCR] [WOS] |
| 38. | Takematsu H, Yamamoto H, Naito-Matsui Y, Fujinawa R, Tanaka K, Okuno Y, Tanaka Y, Kyogashima M, Kannagi R, Kozutsumi Y Quantitative transcriptomic profiling of branching in a glycosphingolipid biosynthetic pathway. Journal of Biological Chemistry 286(31), 27214-27224 (2011) [JCR] [WOS] |
| 39. | Kannagi R, Ohmori K, Chen GY, Miyazaki K, Izawa M, Sakuma K Sialylated and sulfated carbohydrate ligands for selectins and siglecs: involvement in traffic and homing of human memory T and B lymphocytes. Advances in experimental medicine and biology 705, 549-569 (2011) [JCR] [WOS] |
| 40. | Tanaka K, Yamada M, Tamiya-Koizumi K, Kannagi R, Aoyama T, Hara A, Kyogashima M Systematic analyses of free ceramide species and ceramide species comprising neutral glycosphingolipids by MALDI-TOF MS with high-energy CID. Glycoconjugate Journal 28(2), 67-87 (2011) [JCR] [WOS] |
| 41. | Radhakrishnan P, Chachadi V, Lin MF, Singh R, Kannagi R, Cheng PW TNFalpha enhances the motility and invasiveness of prostatic cancer cells by stimulating the expression of selective glycosyl- and sulfotransferase genes involved in the synthesis of selectin ligands. Biochemical and Biophysical Research Communications 409(3), 436-441 (2011) [JCR] [WOS] |
| 42. | Kannagi R, Sakuma K, Miyazaki K, Lim KT, Yusa A, Yin J, Izawa M Altered expression of glycan genes in cancers induced by epigenetic silencing and tumor hypoxia: clues in the ongoing search for new tumor markers. Cancer Science 101(3), 586-593 (2010) [JCR] [WOS] |
| 43. | Yin J, Miyazaki K, Shaner RL, Merrill AH Jr, Kannagi R Altered sphingolipid metabolism induced by tumor hypoxia - new vistas in glycolipid tumor markers. FEBS Letters 584(9), 1872-1878 (2010) [JCR] [WOS] |
| 44. | Fujii M, Yusa A, Yokoyama Y, Kokuryo T, Tsunoda N, Oda K, Nagino M, Ishimaru T, Shimoyama Y, Utsunomiya H, Iwata H, Itoh Y, Itoh J, Kannagi R, Kyogashima M Cytoplasmic expression of the JM403 antigen GlcA-GlcNH3+ on heparan sulfate glycosaminoglycan in mammary carcinomas--a novel proliferative biomarker for breast cancers with high malignancy. Glycoconjugate Journal 27(7-9), 661-672 (2010) [JCR] [WOS] |
| 45. | Yusa A, Miyazaki K, Kimura N, Izawa M, Kannagi R Epigenetic silencing of the sulfate transporter gene DTDST induces sialyl Lewisx expression and accelerates proliferation of colon cancer cells CANCER RESEARCH 70(10), 4064-4073 (2010) [JCR] [WOS] |
| 46. | Ueda M, Shimada T, Goto Y, Tei K, Nakai S, Hisa Y, Kannagi R Expression of CC-chemokine receptor 7 (CCR7) and CXC-chemokine receptor 4 (CXCR4) in head and neck squamous cell carcinoma. AURIS NASUS LARYNX 37(4), 488-495 (2010) [JCR] [WOS] |
| 47. | Igarashi Y, Kannagi R Glycosphingolipids as mediators of phenotypic changes associated with development and cancer progression. Journal of Biochemistry 147(1), 3-8 (2010) [JCR] [WOS] |
| 48. | Ebisuno Y, Katagiri K, Katakai T, Ueda Y, Nemoto T, Inada H, Nabekura J, Okada T, Kannagi R, Tanaka T, Miyasaka M, Hogg N, Kinashi T Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners. Blood 115(4), 804-814 (2010) [JCR] [WOS] |
| 49. | Inoue T, Taguchi I, Abe S, Li G, Hu R, Nakajima T, Hara A, Aoyama T, Kannagi R, Kyogashima M, Node K Sulfatides are associated with neointimal thickening after vascular injury. Atherosclerosis 211(1), 291-296 (2010) [JCR] [WOS] |
| 50. | Varki A, Kannagi R, Toole BP Glycosylation Changes in Cancer Essentials of Glycobiology 617-632 (2009) [JCR] [WOS] |