Dr. Chen, Yuan-Tsong
Corresponding Research Fellow
Academician, Academia Sinica
- 02-27899081 (Lab) (Room No: N807)
- 02-27899085 (Fax)
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Specialty:
- Human Genetics
- Genomic Medicine
Education and Positions:
M.D., Ph.D. Columbia University
Highlight Detail
Mice with Alopecia, Osteoporosis, and Systemic Amyloidosis Due to Mutation in Zdhhc13, a Gene Coding for Palmitoyl Acyltransferase.
Dr. Chen, Yuan-Tsong
PLoS Genet., Jun 10, 2010Protein palmitoylation has emerged as an important mechanism for regulating protein trafficking, stability, and protein–protein interactions; however, its relevance to disease processes is not clear. Using a genome-wide, phenotype driven N-ethyl-N-nitrosourea–mediated mutagenesis screen, we identified mice with failure to thrive, shortened life span, skin and hair abnormalities including alopecia, severe osteoporosis, and systemic amyloidosis (both AA and AL amyloids depositions).