Dr. Shih, Hsiu-Ming 施修明 博士

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重要成果

  • Reciprocal regulation of Daxx and PIK3CA promotes colorectal cancer cell growth
    Cellular and Molecular Life Sciences, Jun 19, 2022
          Upregulation of death-domain-associated protein (Daxx) is strongly associated with diverse cancer types. Among ......
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  • The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis
    Scientific Reports, Jun 28, 2018
      Abstract Smad4, a common-mediator of Smads, plays a central role in forming complexes with receptor-phosphorylated Smads, and ......
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  • Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction
    Scientific Reports, Dec 12, 2017
    The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch of acidic residues downstream of the cons ......
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  • Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression
    Oncotarget, May 27, 2016
    Long noncoding RNAs (lncRNAs) dysregulated in cancer potentially play oncogenic or tumor-suppressive roles. While the X inactivate-specific ......
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  • HIC1 interacts with and modulates the activity of STAT3.
    Cell Cycle., Jun 21, 2013
    Abstract: HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene, expression of which is frequently suppressed in human cancers. Very ......
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