Dr. Tang, Tang K. 唐堂博士 HIGHLIGHT DETAIL 重要成果詳細內容

HIGHLIGHT DETAIL
重要成果詳細內容

Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly.

EMBO J., Mar 19, 2013

Centrioles are cylindrical structures that are usually composed of nine triplets of microtubules (MTs) organized around a cartwheel-shaped structure. Recent studies have proposed a structural model of the SAS-6-based cartwheel, yet we do not know the molecular detail of how the cartwheel participates in centriolar MT assembly.

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A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis
Journal of Biomedical Science Apr 01, 2022
Modeling Human Primary Microcephaly With hiPSC-Derived Brain Organoids Carrying CPAP-E1235V Disease-Associated Mutant Protein
Frontiers in Cell and Developmental Biology Mar 02, 2022
CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum
Genes & Development Oct 28, 2021
Human Microcephaly Protein RTTN Is Required for Proper Mitotic Progression and Correct Spindle Position
Cells Jun 09, 2021
Loss of human microcephaly CPAP in developing mouse brain
J Cell Sci Jun 24, 2020
CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis
Scientific Reports Apr 15, 2019
Myosin-Va is required for preciliary vesicle transportation to the mother centriole during ciliogenesis
Nature Cell Biology Jan 15, 2018
Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles
Nature Communications Aug 15, 2017
Possible role of Aurora-C in meiosis
Frontiers in Oncology Aug 13, 2015
CEP295 interacts with microtubules and is required for centriole elongation
J Cell Science Jul 01, 2016
Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis.
Cell Reports Mar 15, 2016
(invited News and Views article) Centriole biogenesis in multiciliated cells.
Nat Cell Biol. Dec 02, 2013
CEP120 interacts with CPAP and positively regulates centriole elongation.
JCB. Jul 15, 2013
Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly.
EMBO J. Mar 19, 2013
The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation.
EMBO Oct 21, 2011
CPAP is a cell-cycle regulated protein that controls centriole length.
Nat Cell Biol. Jun 07, 2009

HIGHLIGHT DETAIL重要成果詳細內容

Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly.

List of Highlights文件紀錄

HIGHLIGHT DETAIL
重要成果詳細內容

List of Highlights
文件紀錄