Dr. Yen, Jeffrey J.Y. 嚴仲陽 博士



  • Palmitoyl acyltransferase activity of ZDHHC13 regulates skin barrier development partly by controlling PADi3 and TGM1 protein stability
    Journal of Investigative Dermatology, Oct 25, 2019
    Deficiency of the palmitoyl-acyl transferase ZDHHC13 compromises skin barrier permeability and renders mice susceptible to environmental bac ......
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  • CBAP modulates Akt-dependent TSC2 phosphorylation to promote Rheb-mTORC1 signaling and growth of T-cell acute lymphoblastic leukemia
    Oncogene, Sep 29, 2018
    High-frequency relapse remains a clinical hurdle for complete remission of T-cell acute lymphoblastic leukemia (T-ALL) patients, with hetero ......
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  • Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction
    Scientific Reports, Jul 04, 2017
    JAK2 activation is crucial for cytokine receptor signal transduction and leukemogenesis. However, the underlying processes that lead to full ......
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  • Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis
    Journal of Investigative Dermatology, Dec 22, 2016
    Atopic dermatitis (AD) is a complex chronic inflammatory skin disorder that results from intimate interactions between genetic predispositio ......
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  • CBAP interacts with the un-liganded common b-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction.
    Oncogene., Sep 10, 2007
    The cytoplasmic domain of the common -chain (c) of the granulocyte–macrophage-colony-stimulating factor (GM-CSF)/interleukin-3 (IL- ......
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