Dr. Lin, Yi-Ling ’s Lab林宜玲 博士 實驗室

Japanese Encephalitis Virus Nonstructural Protein NS5 Interacts with Mitochondrial Trifunctional Protein and Impairs Fatty Acid β-Oxidation.

Infection with Japanese encephalitis virus (JEV) can induce the expression of pro-inflammatory cytokines and cause acute encephalitis in humans. ?-oxidation breaks down fatty acids for ATP production in mitochondria, and impaired ?-oxidation can induce pro-inflammatory cytokine expression. To address the role of fatty-acid ?-oxidation in JEV infection, we measured the oxygen consumption rate of mock- and JEV-infected cells cultured with or without