Dr. Lin, Yi-Ling
Distinguished Research Fellow
Division Chief
- 02-2789-9013 (Lab) (Room No: 443)
- 02-2652-3902
- 02-2785-8847 (Fax)
-
Specialty:
- Molecular Virology
- Viral Pathogenesis
- Viral Immunology
Education and Positions:
1992, PhD, University of California, Los Angeles (UCLA), USA
2020 ~ date, CEO, Emerging Infectious Disease Division (EIDD), Biomedical Translation Research Center (BioTReC), Academia Sinica
Contact Information:
Highlight Detail
Japanese Encephalitis Virus Nonstructural Protein NS5 Interacts with Mitochondrial Trifunctional Protein and Impairs Fatty Acid β-Oxidation.
Dr. Lin, Yi-Ling
PLoS Pathog., May 27, 2015Infection with Japanese encephalitis virus (JEV) can induce the expression of pro-inflammatory cytokines and cause acute encephalitis in humans. ?-oxidation breaks down fatty acids for ATP production in mitochondria, and impaired ?-oxidation can induce pro-inflammatory cytokine expression. To address the role of fatty-acid ?-oxidation in JEV infection, we measured the oxygen consumption rate of mock- and JEV-infected cells cultured with or without