Dr. Lin, Yi-Ling ’s Lab林宜玲 博士 實驗室


Japanese Encephalitis Virus Nonstructural Protein NS5 Interacts with Mitochondrial Trifunctional Protein and Impairs Fatty Acid β-Oxidation.

PLoS Pathog., May 27, 2015

Infection with Japanese encephalitis virus (JEV) can induce the expression of pro-inflammatory cytokines and cause acute encephalitis in humans. ?-oxidation breaks down fatty acids for ATP production in mitochondria, and impaired ?-oxidation can induce pro-inflammatory cytokine expression. To address the role of fatty-acid ?-oxidation in JEV infection, we measured the oxygen consumption rate of mock- and JEV-infected cells cultured with or without  

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