Dr. Lee, Eminy H.Y. 李小媛 博士

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  • Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation
    Molecular Therapy, Sep 05, 2020
    The amyloid precursor protein (APP) intracellular domain (AICD) is implicated in the pathogenesis of Alzheimer’s disease (AD), but pos ......
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  • Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome
    Scientific Reports, Jan 23, 2020
    The methyl-CpG-binding protein 2 gene, MECP2, is an X chromosome-linked gene encoding the MeCP2 protein, and mutations of MECP2 cause Rett s ......
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  • Galectin-3 promotes Aβ oligomerization and Aβ toxicity in a mouse model of Alzheimer’s disease
    Cell Death & Differentiation, May 24, 2019
    Amyloid-β (Aβ) oligomers largely initiate the cascade underlying the pathology of Alzheimer’s disease (AD). Galectin-3 (Gal- ......
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  • PIAS1 Ser‐503 phosphorylation‐mediated Elk‐1 SUMOylation promotes neuronal survival in APP/PS1 mice
    British Journal of Pharmacology, Mar 08, 2019
    Background and purpose PIAS1 is phosphorylated by IKKα at Ser‐90 in a PIAS1 E3 ligase activity‐dependent manner. Whether PIAS1 is ......
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  • Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2
    BMC Biology, Nov 28, 2017
    BACKGROUND: Smad4 is a critical effector of TGF-β signaling that regulates a variety of cellular functions. However, its role in the ......
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