Dr. Chang, Ya-Jen
Research Fellow
- 02-27899050 (Lab) (Room No: N527)
- 02-27898594 (Fax)
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Specialty:
- Allergy and asthma
- Innate immunity and mucosal immunology
- Immunopharmacology
Education and Positions:
Ph.D., Pharmacology, National Taiwan University;
Instructor in Pediatrics, Harvard Medical School;
Research Associate in Immunology, Boston Children's Hospital
Highlight Detail
The role of type 2 innate lymphoid cells in asthma
Dr. Chang, Ya-Jen
Journal of Leukocyte Biology, Jun 25, 2013Asthma is a complex and heterogeneous disease with several phenotypes, including an allergic asthma phenotype, characterized by Th2 cytokine production and associated with allergen sensitization and adaptive immunity. Asthma also includes nonallergic asthma phenotypes that require innate rather than adaptive immunity. These innate pathways to asthma involve macrophages, neutrophils, as well as ILCs, newly described cell types that produce a variety of cytokines, including IL-5 and IL-13. We review the recent data regarding ILCs and their role in asthma.