Ph.D, State University of New York at Stony Brook, USA
It is known that malignant transformation to hepatocellular carcinoma ( HCC ) occurs at a higher frequency in hepatocellular adenoma (HCA) from type I glycogen storage disease (GSD I) compared to HCA from other etiologies. In this study, we identified several differentially expressed miRNAs in GSD Ia HCA. Among those, miR-130b could serve as a circulating biomarker for detection of GSD Ia HCA.