陳垣崇博士
通信研究員
中央研究院院士
- 02-27899081 (Lab) (Room No: N807)
- 02-27899085 (Fax)
-
Specialty:
- Human Genetics
- Genomic Medicine
Education and Positions:
M.D., Ph.D. Columbia University
Highlight Detail
Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome.
Dr. Chen, Yuan-Tsong
J Allergy Clin Immunol., Feb 07, 2012The endogenous peptide-loaded HLA-B∗1502 molecule presented CBZ to CTLs without the involvement of intracellular drug metabolism or antigen processing. The HLA-B∗1502/peptide/β(2)-microglobulin protein complex showed binding affinity toward chemicals sharing 5-carboxamide on the tricyclic ring, as with CBZ. However, modifications of the ring structure of CBZ altered HLA-B∗1502 binding and CTL response.