Dr. Chen, Yuan-Tsong

Corresponding Research Fellow
Academician, Academia Sinica
  • 02-27899081 (Lab) (Room No: N807)
  • 02-27899085 (Fax)

  • Human Genetics
  • Genomic Medicine

Education and Positions:
  • M.D., Ph.D. Columbia University

Highlight Detail

Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome.

Dr. Chen, Yuan-Tsong
J Allergy Clin Immunol., Feb 07, 2012

The endogenous peptide-loaded HLA-B∗1502 molecule presented CBZ to CTLs without the involvement of intracellular drug metabolism or antigen processing. The HLA-B∗1502/peptide/β(2)-microglobulin protein complex showed binding affinity toward chemicals sharing 5-carboxamide on the tricyclic ring, as with CBZ. However, modifications of the ring structure of CBZ altered HLA-B∗1502 binding and CTL response.