Ph.D., Pharmacology, National Taiwan University;
Instructor in Pediatrics, Harvard Medical School;
Research Associate in Immunology, Boston Children's Hospital
A new immunostimulant, the 4′-epimer of α-CGalCer, was synthesized from a C2-symmetric dienediol and α-C-allyl galactoside. The intramolecular aziridination and the following reductive ring opening provided the core of the aliphatic amino alcohol with excellent regio- and stereocontrol.
The new immunostimulants 3d and 3e gave a better polarized Th1-type cytokine response in murine NKT cells than the benchmarked α-C-GalCer.