Dr. Chang, Ya-Jen 's orcid link picture Dr. Chang, Ya-Jen 's publons link picture

Dr. Chang, Ya-Jen

Associate Research Fellow
  • 02-27899050 (Lab) (Room No: N527)
  • 02-27898594 (Fax)

  1. Allergy and asthma
  2. Innate immunity and mucosal immunology
  3. Immunopharmacology

Education and Positions:
  • Ph.D., Pharmacology, National Taiwan University; 

    Instructor in Pediatrics, Harvard Medical School; 

    Research Associate in Immunology, Boston Children's Hospital

Highlight Detail

Synthesis of α‑C-galactosylceramide via diastereoselective aziridination: the new immunostimulant 4′-epi-C-glycoside of KRN7000.

Dr. Chang, Ya-Jen
Organic Letters, Feb 04, 2016

A new immunostimulant, the 4′-epimer of α-CGalCer, was synthesized from a C2-symmetric dienediol and α-C-allyl galactoside. The intramolecular aziridination and the following reductive ring opening provided the core of the aliphatic amino alcohol with excellent regio- and stereocontrol.

The new immunostimulants 3d and 3e gave a better polarized Th1-type cytokine response in murine NKT cells than the benchmarked α-C-GalCer.