Ph.D, University of Göttingen, Germany (Neuroscience)
Ion channels are membrane proteins that allow certain ions to rapidly cross the membrane. The orchestrated activities of ion channels generate various bioelectric phenomena, including nerve signal propagation, muscle contraction, and hormone release. Moreover, large-scale genetic analyses have identified ion channel mutations that are associated with human diseases. Combining patch-clamp recording with molecular and cell biology, our laboratory is interested in investigating the basic mechanisms that govern ion channel functions and exploring the roles of ion channels under physiological and pathological conditions. Currently, we are focusing on the ion channel mutations that are associated with diseases of the endocrine and nervous systems.
Allosteric coupling between transmembrane segment 4 and the selectivity filter of TALK1 potassium channels regulates their gating by extracellular pH.Journal of Biological Chemistry, Jun 02, 2022
Carbamazepine promotes surface expression of mutant Kir6.2-A28V ATP-sensitive potassium channels by modulating Golgi retention and autophagyJournal of Biological Chemistry, Apr 06, 2022