Dr. Yang, Shi-Bing
Associate Research Fellow
- 2652-3532 (Lab) (Room No: N701)
-
Specialty:
- Neurophysiology
- Energy Metabolism
- Ion channels
Education and Positions:
Ph.D, University of Göttingen, Germany (Neuroscience)
Ion channels are membrane proteins that allow certain ions to rapidly cross the membrane. The orchestrated activities of ion channels generate various bioelectric phenomena, including nerve signal propagation, muscle contraction, and hormone release. Moreover, large-scale genetic analyses have identified ion channel mutations that are associated with human diseases. Combining patch-clamp recording with molecular and cell biology, our laboratory is interested in investigating the basic mechanisms that govern ion channel functions and exploring the roles of ion channels under physiological and pathological conditions. Currently, we are focusing on the ion channel mutations that are associated with diseases of the endocrine and nervous systems.
- Sandra Postić*, Marko Gosak, Wen-Hao Tsai, Johannes Pfabe, Srdjan Sarikas, Andraž Stožer, Dean Korošak, (Shi-Bing Yang) and Marjan Slak Rupnik pH-Dependence of Glucose-Dependent Activity of Beta Cell Networks in Acute Mouse Pancreatic Tissue Slice FRONTIERS IN ENDOCRINOLOGY 13, 916688 (2022-06-28) [JCR] [WOS]
- Wen-Hao Tsai, Cédric Grauffel, Ming-Yueh Huang, Sandra Postić, Marjan Slak Rupnik, Carmay Lim, (Shi-Bing Yang)* Allosteric coupling between transmembrane segment 4 and the selectivity filter of TALK1 potassium channels regulates their gating by extracellular pH JOURNAL OF BIOLOGICAL CHEMISTRY 298(6), 101998 (2022-06-01) [JCR] [WOS]
- Yuan-Hung Lin King, Chao Chen, John V. Lin King, Jeffrey Simms, Edward Glasscock, (Shi-Bing Yang), Yuh-Nung Jan, Lily Yeh Jan* Kv1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 119(22), 2118240119 (2022-05-25) [JCR] [WOS]
- Ching-Han Lin, Yu-Chi Lin, (Shi-Bing Yang)*, Pei-Chun Chen Carbamazepine promotes surface expression of mutant Kir6. 2-A28V ATP-sensitive potassium channels by modulating Golgi retention and autophagy JOURNAL OF BIOLOGICAL CHEMISTRY 298(5), 101904 (2022-05-01) [JCR] [WOS]
- Wen-Ching Lin, Hao-Cheng Tang, Han Ying Wang, Chia-Yi Kao, You-Chiun Chang, Athena Hsu Li, (Shi-Bing Yang), and Kurt Yun Mou* Fragment-Directed Random Mutagenesis by the Reverse Kunkel Method ACS SYNTHETIC BIOLOGY 11(4), 1658-1668 (2022-03-24) [JCR] [WOS]
- Yu-Ju Chou*, Yu-Kai Ma, Yi-Han Lu, Jung-Tai King, Wen-Sheng Tasi, (Shi-Bing Yang)*, Tsung-Han Kuo* Potential cross-species correlations in social hierarchy and memory between mice and young children Communications Biology 5(230), 1-14 (2022-03-14) [JCR] [WOS]
- Shu-Min Chou, Ke-Xin Li, Ming-Yueh Huang, Chao Chen, Yuan-Hung Lin King, Grant Guangnan Li, Wei Zhou, Chin Fen Teo, Yuh Nung Jan, Lily Yeh Jan*, (Shi-Bing Yang)* Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway ELIFE 10, e58779 (2021-05-21) [JCR] [WOS]
- (Yang SB), Jan LY Potassium Channels: Their Physiological and Molecular Diversity Encyclopedia of Biophysics 358-1 (2020-08-14) [JCR] [WOS]
- Lee, Y.H., Hsu, H.C., Yeh, S.H.H., Kao, P.C., Shiao, Y.J., Shie, F.S., Hsu, S.M.a, Yeh, C.W., (Yang, S.B.)*, and Tsay, H.J.* Augmented Insulin and Leptin Resistance of High Fat Diet-Fed APPswe/PS1dE9 Transgenic Mice Exacerbate Obesity and Glycemic Dysregulation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19(8), 2333 (2018-08) [JCR] [WOS]
- Yen-Yu Yang, Roger K. Long, Christine T. Ferrara, Stephen E. Gitelman, Michael S. German & (Shi-Bing Yang)* A new familial form of a late-onset, persistent hyperinsulinemic hypoglycemia of infancy caused by a novel mutation in KCNJ11 CHANNELS 11(6), 636-647 (2017-12) [JCR] [WOS]
POSTDOC
Tsai, Wen-Hao
Li, Athena
RESEARCH ASSOCIATES
Hsu, Yvonne
Su, Amber
STUDENTS
Lin, Shih-Che
ALUMNI
Lu, Kuan-Ming
Chou, Shu-Min
Lee, Ming-Liang
Chen, Hui-Yu
Tsai, Hsin-Ju
Li, Su-Yi
