Dr. Hu, Che-Ming (Jack)
Associate Research Fellow
- 2652-3089 (Lab) (Room No: N534)
- 2788-7641 (Fax)
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Specialty:
Biomaterials and Nanotechnology for Drug and Vaccine Development
Education and Positions:
B.S. University of California, Berkeley (Biomedical Engineering)
Ph.D. University of California, San Diego (Bioengineering)
Advances in bionanotechnology and cargo-carrying nanocarriers enable existing therapeutics to be reformulated to attain higher potency and safety. Nanotechnology in medicine has shown tremendous value in drug delivery and vaccine preparations, where pharmacokinetics and immune activation can be finely tuned via rational nanomaterials engineering. The research focus of the laboratory is to develop novel therapeutic nanomaterials with an emphasis toward clinical translation. By examining and tackling the interface between materials and biology, we seek to adopt an engineering approach to improve treatments for major diseases including cardiovascular disease, cancer, and infectious disease.
Our Team
- Luis E. Contreras-Llano, Yu-Han Liu, Tanner Henson, Conary C. Meyer, Ofelya Baghdasaryan, Shahid Khan, Chi-Long Lin, Aijun Wang, (Che-Ming J. Hu*), Cheemeng Tan* Engineering cyborg bacteria through intracellular hydrogelation ADVANCED SCIENCE e2204175 (2023) [JCR] [WOS]
- Chien Chen‐Ying, Lin Jung‐Chen, Huang Ching‐Ying, Hsu Chung‐Yao, Yang Kai‐Chieh, Chattopadhyay Saborni, Nikoloutsos Nicolas, Hsieh Patrick Ching‐Ho, (Hu Che‐Ming Jack*) In Situ Hydrogelation of Cellular Monolayers Enables Conformal Biomembrane Functionalization for Xeno‐Free Feeder Substrate Engineering Advanced Healthcare Materials 2022, 2201708 (2022-12-16) [JCR] [WOS]
- Chen Charles H., Liu Yu‐Han, Eskandari Arvin, Ghimire Jenisha, Lin Leon Chien‐Wei, Fang Zih‐Syun, Wimley William C., Ulmschneider Jakob P., Suntharalingam Kogularamanan, Hu Che‐Ming Jack, Ulmschneider Martin B. Integrated Design of a Membrane‐Lytic Peptide‐Based Intravenous Nanotherapeutic Suppresses Triple‐Negative Breast Cancer Advanced Science 2105506, 2105506 (2022) [JCR] [WOS]
- Lin JC, Hsu CY, Chen JY, Fang ZS, Chen HW, Yao BY, Shiau GHM, Tsai JS, Gu M, Jung M, Lee TY, Hu CJ Facile Transformation of Murine and Human Primary Dendritic Cells into Robust and Modular Artificial Antigen-Presenting Systems by Intracellular Hydrogelation. ADVANCED MATERIALS epub, e2101190 (2021) [JCR] [WOS]
- Huang Ping-Han, Tsai Hsiao-Han, Liao Bo-Hung, Lin Yi-Ling, Jan Jia-Tsrong, Tao Mi-Hua, Chou Yu-Chi, Hu Che-Ming Jack, Chen Hui-Wen Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain Human Vaccines & Immunotherapeutics 17(3): 654-655, 1-2 (2021) [JCR] [WOS]
- Lin Pin-Hung, Liang Chieh-Yu, Yao Bing-Yu, Chen Hui-Wen, Pan Ching-Fu, Wu Li-Ling, Lin Yi-Hsuan, Hsu Yu-Sung, Liu Yu-Han, Chen Pei-Jer, Jack Hu Che-Ming, Yang Hung-Chih Robust induction of resident memory T cells by combinatorial nanoshells confers cross-strain sterilizing immunity against lethal influenza viruses Molecular Therapy - Methods & Clinical Development 21, 299-314 (2021) [JCR] [WOS]
- Yang Kai-Chieh, Lin Jung-Chen, Tsai Hsiao-Han, Hsu Chung-Yao, Shih Vicky, Hu Che-Ming Jack Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control Drug Delivery and Translational Research DOI: 10.1007/s13346-021-00965-y (2021) [JCR] [WOS]
- Lin Shu-Yi, Yao Bing-Yu, Hu Che-Ming Jack, Chen Hui-Wen Induction of Robust Immune Responses by CpG-ODN-Loaded Hollow Polymeric Nanoparticles for Antiviral and Vaccine Applications in Chickens International Journal of Nanomedicine 15,3303-3318 (2020) [JCR] [WOS]
- Chattopadhyay Saborni, Hu Che-Ming Jack Nanomedicinal delivery of stimulator of interferon genes agonists: recent advances in virus vaccination Nanomedicine 15(29), 2883-2894 (2020) [JCR] [WOS]
- Chattopadhyay Saborni, Liu Yu-Han, Fang Zih-Syun, Lin Chi-Long, Lin Jung-Chen, Yao Bing-Yu, Hu Che-Ming Jack Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo-immunotherapy Nano Letters 20(4), 2246-2256 (2020) [JCR] [WOS]
POSTDOC
Lin, Leon
Lin, jung-Chen
Liu, Seny
Lin, Jeffrey
RESEARCH ASSOCIATES
Yao, Bing-Yu
Hsu, Chung-Yao
STUDENTS
Chattopadhyay, Saborni
Tsai, Sherry
Fang, Angela
Yang, KJ
ALUMNI
Chien, Grace
Tsai, David
Huang, Christine
Hsieh, Cheryl
Hsieh, Ken
Yang, Amber
Chen, Rita
