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Dr. Hu, Che-Ming (Jack)

Associate Research Fellow
  • 2652-3089 (Lab) (Room No: N534)
  • 2788-7641 (Fax)
Specialty:

Biomaterials and Nanotechnology for Drug and Vaccine Development

Education and Positions:

  • B.S. University of California, Berkeley (Biomedical Engineering)

    Ph.D. University of California, San Diego (Bioengineering)

Advances in bionanotechnology and cargo-carrying nanocarriers enable existing therapeutics to be reformulated to attain higher potency and safety. Nanotechnology in medicine has shown tremendous value in drug delivery and vaccine preparations, where pharmacokinetics and immune activation can be finely tuned via rational nanomaterials engineering. The research focus of the laboratory is to develop novel therapeutic nanomaterials with an emphasis toward clinical translation. By examining and tackling the interface between materials and biology, we seek to adopt an engineering approach to improve treatments for major diseases including cardiovascular disease, cancer, and infectious disease.

Our Team
Team photo

Journal 66 Book 0

  1. Lin Chi-Long, Fang Zih-Syun, Hsu Chung-Yao, Liu Yu-Han, Lin Jung-Chen, Yao Bing-Yu, Li Fu-An, Yen Shin-Chwen Bruce, Chang Yuan-Chih,「Hu Che-Ming J*」 Rapid plasma membrane isolation via intracellular polymerization-mediated biomolecular confinement. Acta Biomaterialia 173, 325-335 (2024-01-01) [JCR] [WOS]
  2. Lim S-K, Lin W-C, Huang S-W, Pan Y-C, Hu C-W, Mou C-Y, 「Hu C-M*」, Mou K Bacteria colonization in tumor microenvironment creates a favorable niche for immunogenic chemotherapy. EMBO MOLECULAR MEDICINE (2024) [JCR] [WOS]
  3. Baghdasaryan Ofelya, Khan Shahid, Lin Jung-Chen, Lee-Kin Jared, Hsu Chung-Yao, 「Hu Che-Ming Jack*」, Tan Cheemeng* Synthetic control of living cells by intracellular polymerization. Trends in Biotechnology (2023-09-01) [JCR] [WOS]
  4. Francisco Jamie, Guan Jin, Zhang Yu, Nakada Yasuki, Mareedu Satvik, Sung Eun-Ah, 「Hu Che-Ming」, Oka Shinichi, Zhai Peiyong, Sadoshima Junichi, Del Re Dominic P*. Suppression of myeloid YAP antagonizes adverse cardiac remodeling during pressure overload stress. Journal of Molecular and Cellular Cardiology 181, 1-14 (2023-08-01) [JCR] [WOS]
  5. Tsai Hsiao‐Han, Huang Ping‐Han, Lin Leon CW, Yao Bing‐Yu, Liao Wan‐Ting, Pai Chen‐Hsueh, Liu Yu‐Han, Chen Hui‐Wen*,「Hu Che‐Ming J*」 Lymph Node Follicle‐Targeting STING Agonist Nanoshells Enable Single‐Shot M2e Vaccination for Broad and Durable Influenza Protection. Advanced Science 10(17), 2206521 (2023-04-24) [JCR] [WOS]
  6. Luis E. Contreras-Llano, Yu-Han Liu, Tanner Henson, Conary C. Meyer, Ofelya Baghdasaryan, Shahid Khan, Chi-Long Lin, Aijun Wang, (Che-Ming J. Hu*), Cheemeng Tan* Engineering cyborg bacteria through intracellular hydrogelation. ADVANCED SCIENCE e2204175 (2023) [JCR] [WOS]
  7. Chien Chen‐Ying, Lin Jung‐Chen, Huang Ching‐Ying, Hsu Chung‐Yao, Yang Kai‐Chieh, Chattopadhyay Saborni, Nikoloutsos Nicolas, Hsieh Patrick Ching‐Ho, (Hu Che‐Ming Jack*) In Situ Hydrogelation of Cellular Monolayers Enables Conformal Biomembrane Functionalization for Xeno‐Free Feeder Substrate Engineering. Advanced Healthcare Materials 2022, 2201708 (2022-12-16) [JCR] [WOS]
  8. Chen Charles H., Liu Yu‐Han, Eskandari Arvin, Ghimire Jenisha, Lin Leon Chien‐Wei, Fang Zih‐Syun, Wimley William C., Ulmschneider Jakob P., Suntharalingam Kogularamanan, Hu Che‐Ming Jack, Ulmschneider Martin B. Integrated Design of a Membrane‐Lytic Peptide‐Based Intravenous Nanotherapeutic Suppresses Triple‐Negative Breast Cancer. Advanced Science 2105506, 2105506 (2022) [JCR] [WOS]
  9. Lin JC, Hsu CY, Chen JY, Fang ZS, Chen HW, Yao BY, Shiau GHM, Tsai JS, Gu M, Jung M, Lee TY, Hu CJ Facile Transformation of Murine and Human Primary Dendritic Cells into Robust and Modular Artificial Antigen-Presenting Systems by Intracellular Hydrogelation.. ADVANCED MATERIALS epub, e2101190 (2021) [JCR] [WOS]
  10. Huang Ping-Han, Tsai Hsiao-Han, Liao Bo-Hung, Lin Yi-Ling, Jan Jia-Tsrong, Tao Mi-Hua, Chou Yu-Chi, Hu Che-Ming Jack, Chen Hui-Wen Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain. Human Vaccines & Immunotherapeutics 17(3): 654-655, 1-2 (2021) [JCR] [WOS]
- More Publications-

- POSTDOC -
Lin, Leon
Lin, Leon
Lin, jung-Chen
Lin, jung-Chen
Liu, Seny
Liu, Seny
Lin, Jeffrey
Lin, Jeffrey
- RESEARCH ASSOCIATES -
Yao, Bing-Yu
Yao, Bing-Yu
Hsu, Chung-Yao
Hsu, Chung-Yao
- STUDENTS -
Chattopadhyay, Saborni
Chattopadhyay, Saborni
Tsai, Sherry
Tsai, Sherry
Fang, Angela
Fang, Angela
Yang, KJ
Yang, KJ
- ALUMNI -
Chien, Grace
Chien, Grace
Tsai, David
Tsai, David
Huang, Christine
Huang, Christine
Hsieh, Cheryl
Hsieh, Cheryl
Hsieh, Ken
Hsieh, Ken
Yang, Amber
Yang, Amber
Chen, Rita
Chen, Rita
Hsieh, JX
Hsieh, JX

2019    Excellent Young Investigator Award—Taiwan Biomaterials and Controlled Releases Society

2017    Futuristic Breakthrough Technology Award by Ministry of Science and Technology.

2016    4th Annual Excellence in Creativity Award for Young Scholar

2016    Member of the Global Young Academy
2016    Recipient of the Academia Sinica Career Development Award 
2014    Selected participant of the 64th Meeting of Nobel Laureates
2013    Chancellor’s Postdoctoral Scholar Award, UCSD 2013
2011    Siebel Scholar, Class of 2012 
2010    Best poster award at the 8th NanoDDS
2004    Guidant Undergraduate Research Fellowship