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Dr. Chang, Yi-Cheng

Joint Appointment Associate Research Fellow
  • 02-23123456 ext 88656 (NTU) (Lab) (Room No: 343)
  • 02-33936523 (Fax)
Specialty:
  • Diabetes and Obesity
  • Genetic epidemiology
Education and Positions:

Education:

M.D. -National Taiwan University

Ph.D. -Academia Sinica and National Taiwan University Joint Ph.D. Program of Translational Medicine

 

Position:

- Associate Professor, Graduate Institute of Medical Genomics and Proteomics, Medical College, National Taiwan University

 

- Attending Physician, Department of Endocrinology and Metabolism, National Taiwan University Hospital

 

- Vice CEO, Center for Bariatric and Metabolic Surgery, National Taiwan University Hospital

We focused on East Asian-specific genetic variants of type 2 diabetes, obesity, fatty liver, and kidney diseases. We use transgenic mice to dissect the molecular mechanism, develop small-molecular drugs, and conduct clinical trials.

East Asians are relatively genetically isolated. We participated in large-scale East Asian whole-genome scanning cooperation projects, such as TOPMed and SAPPHIRe. We discovered several novel East Asian-specific genetic variants for diabetes and obesity, such as the acetaldehyde dehydrogenase (ALDH2) mutation (E487K) and Canton-type G6PD genetic mutations.

We found that the ALDH2 East Asian-specific knockin mice developed obesity, abnormal glucose homeostasis, fatty liver, impaired renal function, and cardiomyopathy. We collaborated with Stanford University and pharmaceutical companies to develop potent ALDH2 activators which can scavenge harmful aldehydes and rescue these pathological conditions in mice. Among them, the preventive effect of acute kidney injury of ALDH2 activators will enter the second phase of clinical trials. We are also testing the therapeutic effects of small-molecule G6PD activators that can reverse obesity, abnormal glucose homeostasis, cardiomyopathy, and nephropathy caused by the Canton-type G6PD mutation in mice.

  In addition, we also identified that RRBP1 deficiency in mice caused hyporeninemic hypoaldosteronism, resulting in lower blood pressure, severe hyperkalemia, and sudden cardiac death. In juxtaglomerular cells, deficiency of RRBP1 reduced renin intracellular trafficking from ER to Golgi apparatus. RRBP1 is a brand-new regulator of blood pressure and potassium homeostasis discovered in this study.

Journal 136 Book 5

  1. (Chang Yi-Cheng), Hsieh Meng-Lun, Lee Hsiao-Lin, Hee Siow-Wey, Chang Chi-Fon, Yen Hsin-Yung, Chen Yi-An, Chen Yet-Ran, Chou Ya-Wen, Li Fu-An, Ke Yi-Yu, Chen Shih-Yi, Hung Ming-Shiu, Hung Alfur Fu-Hsin, Huang Jing-Yong, Chiu Chu-Hsuan, Lin Shih-Yao, Shih Sheue-Fang, Hsu Chih-Neng, Hwang Juey-Jen, Yeh Teng-Kuang, Rachel Cheng Ting-Jen, Liao Karen Chia-Wen, Laio Daniel, Lin Shu-Wha, Chen Tzu-Yu, Hu Chun-Mei, Vogel Ulla, Saar Daniel, Kragelund Birthe B., Tsou Lun Kelvin, Tseng Yu-Hua, Chuang Lee-Ming Identification of PTGR2 inhibitors as a new therapy for diabetes and obesity. EMBO MOLECULAR MEDICINE (2024-12-20) [JCR] [WOS]
  2. Lin, H. H., Yu, I. S., Cheng, M. S., Chang, T. J., Lin, H. Y., (Chang, Y. C.), [...], Huang, H. P., Lee, M. S. Spint1 disruption in mouse pancreas leads to glucose intolerance and impaired insulin production involving HEPSIN/MAFA. NATURE COMMUNICATIONS 15(1), 15-10537 (2024-12-03) [JCR] [WOS]
  3. Wu Cyun-Ming, Li Hao-Yun, Li Wen-Yi, Hsu Chih-Neng, Yang Wei-Shun, Chuang Gwo-Tsang, Che Tony Pan-Hou, Lee Tung-Yuan, Lee Hsiao-Lin, Hee Siow-Wey, Lee Jiin-Horng, Liao Daniel, Liao Karen Chia-Wen, Liu Ya-Wen, Hsuan Chin-Feng, Chang Yi-Cheng, Chu Shao-Lun Protocol to measure glucose utilization in mouse tissues using radiolabeled 2-deoxy-D-glucose. STAR Protocols 5(4), 103478 (2024-12) [JCR] [WOS]
  4. Chuang Gwo-Tsann, Hsiung Chia-Ni, Che Tony Pan-Hou, Chang Yi-Cheng Discovering Novel Loci of Chronic Kidney Disease via Principal Component Analysis-Based Multiple-Trait Genome-Wide Association Study. American Journal of Nephrology Online ahead of print., 1-13 (2024-10-21) [JCR] [WOS]
  5. Liu Chia-Ju, Chen Jien-jiun, Wu Jo-Hsuan, Chung Yao-Te, Chen Jin-Wun, Liu Meng-Tsun, Chiu Chu-Hsuan, Chang Yi-Cheng, Chang Sheng-Nan, Lin Jou-Wei, Hwang Juey-Jen Association of exosomes in patients with compromised myocardial perfusion on functional imaging. Journal of the Formosan Medical Association 123(9), 968-974 (2024-09) [JCR] [WOS]
  6. Takahashi Nagahide, Nishimura Tomoko, Okumura Akemi, Harada Taeko, Iwabuchi Toshiki, Rahman Md Shafiur, Liu Pi-Hua, Chuang Gwo-Tsann, Chang Yi-Cheng, Nomura Yoko, Tsuchiya Kenji J. Association between genetic risk of melatonin secretion and attention deficit hyperactivity disorder. Psychiatry Research Communications 4(3), 100188 (2024-07-30) [JCR] [WOS]
  7. Keener R, [...], Chang YC, [...], Battle A. Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes. NATURE COMMUNICATIONS 15(1), 15-4417 (2024-05-24) [JCR] [WOS]
  8. Tsao Hsiao-Mei, Lai Tai-Shuan, (Chang Yi-Cheng), Hsiung Chia-Ni, Tsai I-Jung, Chou Yu-Hsiang, Wu Vin-Cent, Lin Shuei-Liong, Chen Yung-Ming A multi-trait GWAS identifies novel genes influencing albuminuria. Nephrology Dialysis Transplantation 40(1), 123-132 (2024-05-21) [JCR] [WOS]
  9. Hee Siow-Wey, Chang Yi-Cheng, Su Lynn, Chen Ing-Jung, Jeng Yung-Ming, Hsieh Meng-Lun, Chang Yu-Chia, Li Fu-An, Liao Daniel, Chen Shiau-Mei, Chuang Lee-Ming 15-keto-PGE2 alleviates nonalcoholic steatohepatitis through its covalent modification of NF-κB factors. iScience 26(10), 107997 (2023-10) [JCR] [WOS]
  10. Chang Yi-Cheng, Lee Hsiao-Lin, Yang Wenjin, Hsieh Meng-Lun, Liu Cai-Cin, Lee Tung-Yuan, Huang Jing-Yong, Nong Jiun-Yi, Li Fu-An, Chuang Hsiao-Li, Ding Zhi-Zhong, Su Wei-Lun, Chueh Li-Yun, Tsai Yi-Ting, Chen Che-Hong, Mochly-Rosen Daria, Chuang Lee-Ming A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators. Nature Communications 14(1), 1-16 (2023-09-25) [JCR] [WOS]
- More Publications-

- POSTDOC -
Hsiao-Lin, Lee
Hsiao-Lin, Lee
- RESEARCH ASSOCIATES -
Lee, Jiin Horng
Lee, Jiin Horng
member
HSIEH, MIN-HSIEN
member
CHEN, TZU-CHIEH
member
NUNG, CHUN-YI
- STUDENTS -
Tung-Yuan, Lee
Tung-Yuan, Lee
Gwo-Tsann, Chuang
Gwo-Tsann, Chuang
Yang, Wei-Shun
Yang, Wei-Shun
Che, Tony Pan-Hou
Che, Tony Pan-Hou
- ALUMNI -
member
Chu-Hsien, Chou
member
Cai-Cing, Liu
member
Meng-Lun, Hsieh
member
Jing-Yong, Huang
member
Wei-Lun, Su
member
Li-Yun, CHUEH
member
Chou, Yun Ju
member
Lee, Mei-Hua
member
Kuo, Yu Chieh

1. 1998 臺灣大學醫學系書卷獎
2. 2004  臺大內科住院醫師學術優異獎
3. 2006 國衛院醫師攻讀臨床在職專班獎助 
4. 2007  中華民國糖尿病學會默沙東優秀論文獎
5. 2008 Peter Bennett’s Award, IDF/WPR Asia-Pacific Diabetes Epidemiology and
Education Training Course
6. 2008 Human Genome Organization (HUGO) Young Investigator Award
7. 2008 華夏內分泌學會年輕傑出研究獎
8. Top 10 Cited Paper (2010) Metabolism: Clinical and Experimental
9. 2013  中華民國糖尿病學會輝瑞優秀論文獎
10. 2014 中華民國糖尿病學會諾和諾德糖尿病傑出研究獎
11. 2016 臺大醫學院研究生優秀著作獎
12. 2016, 2020 年中華民國糖尿病學會研究計劃獎勵
13. 2016 跨世紀醫療促進基金會醫學研究獎
14. 2015,2017, 2018, 2021學年台灣大學學術研究績效獎勵
15. 2019 科技部未來科技突破獎 (台灣大學與國家衛生研究院團隊)
16. 2019臺灣醫學會雜誌年度最佳審查人獎
17. 臺大醫學院及臺大醫院兩院轉譯醫學2005, 2019, 2021,2022, 2023 獲獎團隊
18. 2024台灣大學資深優良教師
19. 2024中華民國糖尿病學會傑出研究獎

1. Academic Performance Award, National Taiwan University (1998)
2. Distinguished Academic Achievement Award of Residents, Department of Internal Medicine, National Taiwan University Hospital (2004)
3. Medical Research Award for Physicians in Working Professional Master’s Program, National Health Research Institutes, Taiwan (2006)
4. MSD Distinguished Research Paper Award, Diabetes Association of Taiwan (2007)
5. Peter Bennett’s Award, IDF/WPR Asia-Pacific Diabetes Epidemiology and Education Training Course (2008)
6. Young Investigator Award, Human Genome Organization (HUGO) (2008)
7. Young Investigator Award, 5th Huaxia Congress of Endocrinology (2008)
8. Top 10 Cited Paper of Metabolism (2010)
9. Pfizer Distinguished Research Paper Award, Diabetes Association of Taiwan (2013)
10. Novo Nordisk Distinguished Research Award, Diabetes Association of Taiwan (2014)
11. Outstanding Research Award for Graduate Students of National Taiwan University School of Medicine (2016)
12. Research Program Award of the Diabetes Society of the Republic of China (Taiwan) (2016, 2020)
13. Outstanding Research Award of the New Century Health Care Promotion Foundation (2016)
14. Academic Research Performance Award, National Taiwan University (2015, 2017, 2018, 2021)
15. Future Technology Breakthrough Award, Ministry of Science and Technology, Taiwan (2019)
16. Best Reviewer Award, Journal of Formosan Medical Association 2019
17. Translational Research Award of National Taiwan University Medical College and National Taiwan University (2018.2019, 2021, 2022, 2023)
18. Senior Excellent Teacher Award, National Taiwan University (2024)
19. Distinguished Research Award, Diabetes Association of Taiwan (2024)