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Dr. Chang, Yi-Cheng

Joint Appointment Assistant Research Fellow
  • 02-23123456 ext 88656 (NTU) (Lab) (Room No: 343)
  • 02-33936523 (Fax)

Specialty:
  • Diabetes and Obesity
  • Genetic epidemiology

Education and Positions:
  • Education:

    M.D. -National Taiwan University

    Ph.D. -Academia Sinica and National Taiwan University Joint Ph.D. Program of Translational Medicine

     

    Position:

    - Associate Professor, Graduate Institute of Medical Genomics and Proteomics, Medical College, National Taiwan University

     

    - Attending Physician, Department of Endocrinology and Metabolism, National Taiwan University Hospital

     

    - Vice CEO, Center for Bariatric and Metabolic Surgery, National Taiwan University Hospital


We focused on East Asian-specific genetic variants of type 2 diabetes, obesity, fatty liver, and kidney diseases. We use transgenic mice to dissect the molecular mechanism, develop small-molecular drugs, and conduct clinical trials.

East Asians are relatively genetically isolated. We participated in large-scale East Asian whole-genome scanning cooperation projects, such as TOPMed and SAPPHIRe. We discovered several novel East Asian-specific genetic variants for diabetes and obesity, such as the acetaldehyde dehydrogenase (ALDH2) mutation (E487K) and Canton-type G6PD genetic mutations.

We found that the ALDH2 East Asian-specific knockin mice developed obesity, abnormal glucose homeostasis, fatty liver, impaired renal function, and cardiomyopathy. We collaborated with Stanford University and pharmaceutical companies to develop potent ALDH2 activators which can scavenge harmful aldehydes and rescue these pathological conditions in mice. Among them, the preventive effect of acute kidney injury of ALDH2 activators will enter the second phase of clinical trials. We are also testing the therapeutic effects of small-molecule G6PD activators that can reverse obesity, abnormal glucose homeostasis, cardiomyopathy, and nephropathy caused by the Canton-type G6PD mutation in mice.

  In addition, we also identified endogenous PPARγ ligands and used genetic knockout mice to confirm that increasing the endogenous PPARγ ligand can reduce obesity, fatty liver, and improve glucose homeostasis without the side effect of synthetic PPARγ ligands (thiazolidinediones) such as obesity, water retention, and osteoporosis. We further develop small-molecule PTGR2 inhibitors that can increase endogenous PPARγ ligands, improve glucose homeostasis, and reduce obesity and fatty liver in mice.

  1. Lu JY, Ou HY, Wu CZ, Yang CY, Jiang JY, Lu CH, Jiang YD, Chang TJ, Chang YC, Hsieh ML, Wu WC, Li HY, Du YF, Lin CH, Hung HC, Tien KJ, Yeh NC, Lee SY, Yu HI, Chuang LM A randomized trial on the effect of transcutaneous electrical nerve stimulator on glycemic control in patients with type 2 diabetes. Scientific reports 13(1), 2662 (2023) [JCR] [WOS]
  2. Chiu CH, Hsuan CF, Lin SH, Hung YJ, Hwu CM, Hee SW, Lin SW, Fong SW, Hsieh PC, Yang WS, Lin WC, Lee HL, Hsieh ML, Li WY, Lin JW, Hsu CN, Wu VC, Chuang GT, Chang YC, Chuang LM ER ribosomal-binding protein 1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking. Journal of biomedical science 30(1), 13 (2023) [JCR] [WOS]
  3. Laiman J, Hsu YJ, Loh J, Tang WC, Chuang MC, Liu HK, Yang WS, Chen BC, Chuang LM, Chang YC, Liu YW GSK3alpha phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells. The Journal of cell biology 222(2), e202102119 (2023) [JCR] [WOS]
  4. Tsao HM, Lai TS, Chang YC, Hsiung CN, Chou YH, Wu VC, Lin SL, Chen YM Serum Urate and Risk of Chronic Kidney Disease: A Mendelian Randomization Study Using Taiwan Biobank. Mayo Clinic proceedings S0025-6196(23), 23 (2023) [JCR] [WOS]
  5. Liu PH, Chuang GT, Hsiung CN, Yang WS, Ku HC, Lin YC, Chen YS, Huang YY, Lin CH, Li WY, Lin JW, Hsu CN, Hwang JJ, Liao KC, Hsieh ML, Lee HL, Shen CY, Chang YC A genome-wide association study for melatonin secretion. Scientific reports 12(1), 8025 (2022) [JCR] [WOS]
  6. Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU, Jiang Y, Raghavan S, Miao J, Arias JD, Graham SE, Mukamel RE, Spracklen CN, Yin X, Chen SH, Ferreira T, Highland HH, Ji Y, Karaderi T, Lin K, Lull K, Malden DE, Medina-Gomez C, Machado M, Moore A, Rueger S, Sim X, Vrieze S, Ahluwalia TS, Akiyama M, Allison MA, Alvarez M, Andersen MK, Ani A, Appadurai V, Arbeeva L, Bhaskar S, Bielak LF, Bollepalli S, Bonnycastle LL, Bork-Jensen J, Bradfield JP, Bradford Y, Braund PS, Brody JA, Burgdorf KS, Cade BE, Cai H, Cai Q, Campbell A, Canadas-Garre M, Catamo E, Chai JF, Chai X, Chang LC, Chang YC, Chen CH, Chesi A, Choi SH, Chung RH, Cocca M, Concas MP, Couture C, Cuellar-Partida G, Danning R, Daw EW, Degenhard F, Delgado GE, Delitala A, Demirkan A, Deng X, Devineni P, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Ekici AB, Engmann JE, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Francescatto M, Freitag-Wolf S, Fuchsberger C, Galesloot TE, Gao Y, Gao Z, Geller F, Giannakopoulou O, Giulianini F, Gjesing AP, Goel A, Gordon SD, Gorski M, Grove J, Guo X, Gustafsson S, Haessler J, Hansen TF, Havulinna AS, Haworth SJ, He J, Heard-Costa N, Hebbar P, Hindy G, Ho YA, Hofer E, Holliday E, Horn K, Hornsby WE, Hottenga JJ, Huang H, Huang J, Huerta-Chagoya A, Huffman JE, Hung YJ, Huo S, Hwang MY, Iha H, Ikeda DD, Isono M, Jackson AU, Jager S, Jansen IE, Johansson I, Jonas JB, Jonsson A, Jorgensen T, Kalafati IP, Kanai M, Kanoni S, Karhus LL, Kasturiratne A, Katsuya T, Kawaguchi T, Kember RL, Kentistou KA, Kim HN, Kim YJ, Kleber ME, Knol MJ, Kurbasic A, Lauzon M, Le P, Lea R, Lee JY, Leonard HL, Li SA, Li X, Li X, Liang J, Lin H, Lin SY, Liu J, Liu X, Lo KS, Long J, Lores-Motta L, Luan J, Lyssenko V, Lyytikainen LP, Mahajan A, Mamakou V, Mangino M, Manichaikul A, Marten J, Mattheisen M, Mavarani L, McDaid AF, Meidtner K, Melendez TL, Mercader JM, Milaneschi Y, Miller JE, Millwood IY, Mishra PP, Mitchell RE, Mollehave LT, Morgan A, Mucha S, Munz M, Nakatochi M, Nelson CP, Nethander M, Nho CW, Nielsen AA, Nolte IM, Nongmaithem SS, Noordam R, Ntalla I, Nutile T, Pandit A, Christofidou P, Parna K, Pauper M, Petersen ERB, Petersen LV, Pitkanen N, Polasek O, Poveda A, Preuss MH, Pyarajan S, Raffield LM, Rakugi H, Ramirez J, Rasheed A, Raven D, Rayner NW, Riveros C, Rohde R, Ruggiero D, Ruotsalainen SE, Ryan KA, Sabater-Lleal M, Saxena R, Scholz M, Sendamarai A, Shen B, Shi J, Shin JH, Sidore C, Sitlani CM, Slieker RC, Smit RAJ, Smith AV, Smith JA, Smyth LJ, Southam L, Steinthorsdottir V, Sun L, Takeuchi F, Tallapragada DSP, Taylor KD, Tayo BO, Tcheandjieu C, Terzikhan N, Tesolin P, Teumer A, Theusch E, Thompson DJ, Thorleifsson G, Timmers PRHJ, Trompet S, Turman C, Vaccargiu S, van der Laan SW, van der Most PJ, van Klinken JB, van Setten J, Verma SS, Verweij N, Veturi Y, Wang CA, Wang C, Wang L, Wang Z, Warren HR, Bin Wei W, Wickremasinghe AR, Wielscher M, Wiggins KL, Winsvold BS, Wong A, Wu Y, Wuttke M, Xia R, Xie T, Yamamoto K, Yang J, Yao J, Young H, Yousri NA, Yu L, Zeng L, Zhang W, Zhang X, Zhao JH, Zhao W, Zhou W, Zimmermann ME, Zoledziewska M, Adair LS, Adams HHH, Aguilar-Salinas CA, Al-Mulla F, Arnett DK, Asselbergs FW, Asvold BO, Attia J, Banas B, Bandinelli S, Bennett DA, Bergler T, Bharadwaj D, Biino G, Bisgaard H, Boerwinkle E, Boger CA, Bonnelykke K, Boomsma DI, Borglum AD, Borja JB, Bouchard C, Bowden DW, Brandslund I, Brumpton B, Buring JE, Caulfield MJ, Chambers JC, Chandak GR, Chanock SJ, Chaturvedi N, Chen YI, Chen Z, Cheng CY, Christophersen IE, Ciullo M, Cole JW, Collins FS, Cooper RS, Cruz M, Cucca F, Cupples LA, Cutler MJ, Damrauer SM, Dantoft TM, de Borst GJ, de Groot LCPGM, De Jager PL, de Kleijn DPV, Janaka de Silva H, Dedoussis GV, den Hollander AI, Du S, Easton DF, Elders PJM, Eliassen AH, Ellinor PT, Elmstahl S, Erdmann J, Evans MK, Fatkin D, Feenstra B, Feitosa MF, Ferrucci L, Ford I, Fornage M, Franke A, Franks PW, Freedman BI, Gasparini P, Gieger C, Girotto G, Goddard ME, Golightly YM, Gonzalez-Villalpando C, Gordon-Larsen P, Grallert H, Grant SFA, Grarup N, Griffiths L, Gudnason V, Haiman C, Hakonarson H, Hansen T, Hartman CA, Hattersley AT, Hayward C, Heckbert SR, Heng CK, Hengstenberg C, Hewitt AW, Hishigaki H, Hoyng CB, Huang PL, Huang W, Hunt SC, Hveem K, Hypponen E, Iacono WG, Ichihara S, Ikram MA, Isasi CR, Jackson RD, Jarvelin MR, Jin ZB, Jockel KH, Joshi PK, Jousilahti P, Jukema JW, Kahonen M, Kamatani Y, Kang KD, Kaprio J, Kardia SLR, Karpe F, Kato N, Kee F, Kessler T, Khera AV, Khor CC, Kiemeney LALM, Kim BJ, Kim EK, Kim HL, Kirchhof P, Kivimaki M, Koh WP, Koistinen HA, Kolovou GD, Kooner JS, Kooperberg C, Kottgen A, Kovacs P, Kraaijeveld A, Kraft P, Krauss RM, Kumari M, Kutalik Z, Laakso M, Lange LA, Langenberg C, Launer LJ, Le Marchand L, Lee H, Lee NR, Lehtimaki T, Li H, Li L, Lieb W, Lin X, Lind L, Linneberg A, Liu CT, Liu J, Loeffler M, London B, Lubitz SA, Lye SJ, Mackey DA, Magi R, Magnusson PKE, Marcus GM, Vidal PM, Martin NG, Marz W, Matsuda F, McGarrah RW, McGue M, McKnight AJ, Medland SE, Mellstrom D, Metspalu A, Mitchell BD, Mitchell P, Mook-Kanamori DO, Morris AD, Mucci LA, Munroe PB, Nalls MA, Nazarian S, Nelson AE, Neville MJ, Newton-Cheh C, Nielsen CS, Nothen MM, Ohlsson C, Oldehinkel AJ, Orozco L, Pahkala K, Pajukanta P, Palmer CNA, Parra EJ, Pattaro C, Pedersen O, Pennell CE, Penninx BWJH, Perusse L, Peters A, Peyser PA, Porteous DJ, Posthuma D, Power C, Pramstaller PP, Province MA, Qi Q, Qu J, Rader DJ, Raitakari OT, Ralhan S, Rallidis LS, Rao DC, Redline S, Reilly DF, Reiner AP, Rhee SY, Ridker PM, Rienstra M, Ripatti S, Ritchie MD, Roden DM, Rosendaal FR, Rotter JI, Rudan I, Rutters F, Sabanayagam C, Saleheen D, Salomaa V, Samani NJ, Sanghera DK, Sattar N, Schmidt B, Schmidt H, Schmidt R, Schulze MB, Schunkert H, Scott LJ, Scott RJ, Sever P, Shiroma EJ, Shoemaker MB, Shu XO, Simonsick EM, Sims M, Singh JR, Singleton AB, Sinner MF, Smith JG, Snieder H, Spector TD, Stampfer MJ, Stark KJ, Strachan DP, \'t Hart LM, Tabara Y, Tang H, Tardif JC, Thanaraj TA, Timpson NJ, Tonjes A, Tremblay A, Tuomi T, Tuomilehto J, Tusie-Luna MT, Uitterlinden AG, van Dam RM, van der Harst P, Van der Velde N, van Duijn CM, van Schoor NM, Vitart V, Volker U, Vollenweider P, Volzke H, Wacher-Rodarte NH, Walker M, Wang YX, Wareham NJ, Watanabe RM, Watkins H, Weir DR, Werge TM, Widen E, Wilkens LR, Willemsen G, Willett WC, Wilson JF, Wong TY, Woo JT, Wright AF, Wu JY, Xu H, Yajnik CS, Yokota M, Yuan JM, Zeggini E, Zemel BS, Zheng W, Zhu X, Zmuda JM, Zonderman AB, Zwart JA, Chasman DI, Cho YS, Heid IM, McCarthy MI, Ng MCY, O\'Donnell CJ, Rivadeneira F, Thorsteinsdottir U, Sun YV, Tai ES, Boehnke M, Deloukas P, Justice AE, Lindgren CM, Loos RJF, Mohlke KL, North KE, Stefansson K, Walters RG, Winkler TW, Young KL, Loh PR, Yang J, Esko T, Assimes TL, Auton A, Abecasis GR, Willer CJ, Locke AE, Berndt SI, Lettre G, Frayling TM, Okada Y, Wood AR, Visscher PM, Hirschhorn JN A saturated map of common genetic variants associated with human height. Nature 610(7933), 704-712 (2022) [JCR] [WOS]
  7. Wainschtein P, Jain D, Zheng Z, Cupples LA, Shadyab AH, McKnight B, Shoemaker BM, Mitchell BD, Psaty BM, Kooperberg C, Liu CT, Albert CM, Roden D, Chasman DI, Darbar D, Lloyd-Jones DM, Arnett DK, Regan EA, Boerwinkle E, Rotter JI, O\'Connell JR, Yanek LR, de Andrade M, Allison MA, McDonald MN, Chung MK, Fornage M, Chami N, Smith NL, Ellinor PT, Vasan RS, Mathias RA, Loos RJF, Rich SS, Lubitz SA, Heckbert SR, Redline S, Guo X, Chen Y-I, Laurie CA, Hernandez RD, McGarvey ST, Goddard ME, Laurie CC, North KE, Lange LA, Weir BS, Yengo L, Yang J, Visscher PM Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data. Nature genetics 54(3), 263-273 (2022) [JCR] [WOS]
  8. Lin CH, Lai YC, Chang TJ, Jiang YD, Chang YC, Chuang LM Hemoglobin glycation index predicts renal function deterioration in patients with type 2 diabetes and a low risk of chronic kidney disease. Diabetes research and clinical practice 186, 109834 (2022) [JCR] [WOS]
  9. Sharma A, Razaghizad A, Ferreira JP, Machu JL, Bozec E, Girerd N, Rossignol P, Zannad F Metabolic Syndrome and the Risk of Preclinical Heart Failure: Insights after 17 Years of Follow-Up from the STANISLAS Cohort. Cardiology 147(3), 281-287 (2022) [JCR] [WOS]
  10. Lin CS, Chang CC, Yeh CC, Chang YC, Chen TL, Liao CC Outcomes following diabetes admission in patients who had influenza vaccination: A population-based cohort study. Diabetes research and clinical practice 189, 109930 (2022) [JCR] [WOS]

POSTDOC
Hsiao-Lin, Lee
Hsiao-Lin, Lee
RESEARCH ASSOCIATES
Jing-Yong, Huang
Jing-Yong, Huang
Chou, Yun Ju
Chou, Yun Ju
Lee, Mei-Hua
Lee, Mei-Hua
STUDENTS
Chu-Hsien, Chou
Chu-Hsien, Chou
Gwo-Tsann, Chuang
Gwo-Tsann, Chuang
Yang, Wei-Shun
Yang, Wei-Shun
Che, Tony Pan-Hou
Che, Tony Pan-Hou
Kuo, Yu Chieh
Kuo, Yu Chieh
Lee, Jiin Horng
Lee, Jiin Horng
ALUMNI
Cai-Cing, Liu
Cai-Cing, Liu
Meng-Lun, Hsieh
Meng-Lun, Hsieh
Wei-Lun, Su
Wei-Lun, Su
Tung-Yuan, Lee
Tung-Yuan, Lee
Li-Yun, CHUEH
Li-Yun, CHUEH