Dr. Chang, Yi-Cheng
Joint Appointment Assistant Research Fellow
- 02-23123456 ext 88656 (NTU) (Lab) (Room No: 343)
- 02-33936523 (Fax)
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Specialty:
- Diabetes and Obesity
- Genetic epidemiology
Education and Positions:
Education:
M.D. -National Taiwan University
Ph.D. -Academia Sinica and National Taiwan University Joint Ph.D. Program of Translational Medicine
Position:
- Associate Professor, Graduate Institute of Medical Genomics and Proteomics, Medical College, National Taiwan University
- Attending Physician, Department of Endocrinology and Metabolism, National Taiwan University Hospital
- Vice CEO, Center for Bariatric and Metabolic Surgery, National Taiwan University Hospital
We focused on East Asian-specific genetic variants of type 2 diabetes, obesity, fatty liver, and kidney diseases. We use transgenic mice to dissect the molecular mechanism, develop small-molecular drugs, and conduct clinical trials.
East Asians are relatively genetically isolated. We participated in large-scale East Asian whole-genome scanning cooperation projects, such as TOPMed and SAPPHIRe. We discovered several novel East Asian-specific genetic variants for diabetes and obesity, such as the acetaldehyde dehydrogenase (ALDH2) mutation (E487K) and Canton-type G6PD genetic mutations.
We found that the ALDH2 East Asian-specific knockin mice developed obesity, abnormal glucose homeostasis, fatty liver, impaired renal function, and cardiomyopathy. We collaborated with Stanford University and pharmaceutical companies to develop potent ALDH2 activators which can scavenge harmful aldehydes and rescue these pathological conditions in mice. Among them, the preventive effect of acute kidney injury of ALDH2 activators will enter the second phase of clinical trials. We are also testing the therapeutic effects of small-molecule G6PD activators that can reverse obesity, abnormal glucose homeostasis, cardiomyopathy, and nephropathy caused by the Canton-type G6PD mutation in mice.
In addition, we also identified endogenous PPARγ ligands and used genetic knockout mice to confirm that increasing the endogenous PPARγ ligand can reduce obesity, fatty liver, and improve glucose homeostasis without the side effect of synthetic PPARγ ligands (thiazolidinediones) such as obesity, water retention, and osteoporosis. We further develop small-molecule PTGR2 inhibitors that can increase endogenous PPARγ ligands, improve glucose homeostasis, and reduce obesity and fatty liver in mice.
- Dec 05, 2019 科技部未來科技突破獎
2019
- Hee Siow-Wey, Chang Yi-Cheng, Su Lynn, Chen Ing-Jung, Jeng Yung-Ming, Hsieh Meng-Lun, Chang Yu-Chia, Li Fu-An, Liao Daniel, Chen Shiau-Mei, Chuang Lee-Ming 15-keto-PGE2 alleviates nonalcoholic steatohepatitis through its covalent modification of NF-κB factors iScience 26(10), 107997 (2023-10) [JCR] [WOS]
- Chang Yi-Cheng, Lee Hsiao-Lin, Yang Wenjin, Hsieh Meng-Lun, Liu Cai-Cin, Lee Tung-Yuan, Huang Jing-Yong, Nong Jiun-Yi, Li Fu-An, Chuang Hsiao-Li, Ding Zhi-Zhong, Su Wei-Lun, Chueh Li-Yun, Tsai Yi-Ting, Chen Che-Hong, Mochly-Rosen Daria, Chuang Lee-Ming A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators Nature Communications 14(1), 1-16 (2023-09-25) [JCR] [WOS]
- Chang Yi-Cheng, Hsu Chih-Neng, Chong Keong, Yang Po-Jen, Ser Kong-Han, Lee Po-Chu, Chen Shu-Chun, Hsuan Chin-Feng, Lee Yi-Chih, Hsu Chih-Cheng, Lee Hsiao-Lin, Liao Karen Chia-Wen, Hsieh Meng-Lun, Chuang Gwo-Tsann, Yang Wei-Shun, Chu Shao-Lun, Li Wen-Yi, Chuang Lee-Ming, Lee Wei-Jei Roux-en-Y and One-Anastomosis Gastric Bypass Surgery Are Superior to Sleeve Gastrectomy in Lowering Glucose and Cholesterol Levels Independent of Weight Loss: a Propensity-Score Weighting Analysis Obesity Surgery 33(10), 3035-3050 (2023-08-24) [JCR] [WOS]
- Yang Wei-shun, Chuang Gwo-Tsann, Che Tony Pan-Hou, Chueh Li-Yun, Li Wen-Yi, Hsu Chih-Neng, Hsiung Chia-Ni, Ku Hsiao-Chia, Lin Yi-Ching, Chen Yi-Shun, Hee Siow-Wey, Chang Tien-Jyun, Chen Shiau-Mei, Hsieh Meng-Lun, Lee Hsiao-Lin, Liao Karen Chia-Wen, Shen Chen-Yang, Chang Yi-Cheng Genome-Wide Association Studies for Albuminuria of Nondiabetic Taiwanese Population American Journal of Nephrology Online publication, 1-11 (2023-07-12) [JCR] [WOS]
- Williamson Alice, Norris Dougall M., Yin Xianyong, Broadaway K. Alaine, Moxley Anne H., Vadlamudi Swarooparani, Wilson Emma P., Jackson Anne U., Ahuja Vasudha, Andersen Mette K., Arzumanyan Zorayr, Bonnycastle Lori L., Bornstein Stefan R., Bretschneider Maxi P., Buchanan Thomas A., Chang Yi-Cheng, Chuang Lee-Ming, Chung Ren-Hua, Clausen Tine D., Damm Peter, Delgado Graciela E., de Mello Vanessa D., Dupuis Josée, Dwivedi Om P., Erdos Michael R., Silva Lilian Fernandes, Frayling Timothy M., Gieger Christian, Goodarzi Mark O., Guo Xiuqing, Gustafsson Stefan, Hakaste Liisa, Hammar Ulf, Hatem Gad, Herrmann Sandra, Højlund Kurt, Horn Katrin, Hsueh Willa A., Hung Yi-Jen, Hwu Chii-Min, Jonsson Anna, Kårhus Line L., Kleber Marcus E., Kovacs Peter, Lakka Timo A., Lauzon Marie, Lee I-Te, Lindgren Cecilia M., Lindström Jaana, Linneberg Allan, Liu Ching-Ti, Luan Jian’an, Aly Dina Mansour, Mathiesen Elisabeth, Moissl Angela P., Morris Andrew P., Narisu Narisu, Perakakis Nikolaos, Peters Annette, Prasad Rashmi B., Rodionov Roman N., Roll Kathryn, Rundsten Carsten F., Sarnowski Chloé, Savonen Kai, Scholz Markus, Sharma Sapna, Stinson Sara E., Suleman Sufyan, Tan Jingyi, Taylor Kent D., Uusitupa Matti, Vistisen Dorte, Witte Daniel R., Walther Romy, Wu Peitao, Xiang Anny H., Zethelius Björn, de Mello Vanessa D., Ahlqvist Emma, Bergman Richard N., Chen Yii-Der Ida, Collins Francis S., Fall Tove, Florez Jose C., Fritsche Andreas, Grallert Harald, Groop Leif, Hansen Torben, Koistinen Heikki A., Komulainen Pirjo, Laakso Markku, Lind Lars, Loeffler Markus, März Winfried, Meigs James B., Raffel Leslie J., Rauramaa Rainer, Rotter Jerome I., Schwarz Peter E. H., Stumvoll Michael, Sundström Johan, Tönjes Anke, Tuomi Tiinamaija, Tuomilehto Jaakko, Wagner Robert, Barroso Inês, Walker Mark, Grarup Niels, Boehnke Michael, Wareham Nicholas J., Mohlke Karen L., Wheeler Eleanor, O’Rahilly Stephen, Fazakerley Daniel J., Langenberg Claudia, Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake Nature Genetics 55(6), 973-983 (2023-06) [JCR] [WOS]
- Hsuan Chin-Feng, Teng Sean I. F., Hsu Chih-Neng, Liao Daniel, Chang Allen Jiun-Wei, Lee Hsiao-Lin, Hee Siow-Wey, Chang Yi-Cheng, Chuang Lee-Ming Emerging Therapy for Diabetic Cardiomyopathy: From Molecular Mechanism to Clinical Practice Biomedicines 11(3), 662 (2023-02-22) [JCR] [WOS]
- Lu JY, Ou HY, Wu CZ, Yang CY, Jiang JY, Lu CH, Jiang YD, Chang TJ, Chang YC, Hsieh ML, Wu WC, Li HY, Du YF, Lin CH, Hung HC, Tien KJ, Yeh NC, Lee SY, Yu HI, Chuang LM A randomized trial on the effect of transcutaneous electrical nerve stimulator on glycemic control in patients with type 2 diabetes. Scientific reports 13(1), 2662 (2023) [JCR] [WOS]
- Chiu CH, Hsuan CF, Lin SH, Hung YJ, Hwu CM, Hee SW, Lin SW, Fong SW, Hsieh PC, Yang WS, Lin WC, Lee HL, Hsieh ML, Li WY, Lin JW, Hsu CN, Wu VC, Chuang GT, Chang YC, Chuang LM ER ribosomal-binding protein 1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking. Journal of biomedical science 30(1), 13 (2023) [JCR] [WOS]
- Laiman J, Hsu YJ, Loh J, Tang WC, Chuang MC, Liu HK, Yang WS, Chen BC, Chuang LM, Chang YC, Liu YW GSK3alpha phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells. The Journal of cell biology 222(2), e202102119 (2023) [JCR] [WOS]
- Tsao HM, Lai TS, Chang YC, Hsiung CN, Chou YH, Wu VC, Lin SL, Chen YM Serum Urate and Risk of Chronic Kidney Disease: A Mendelian Randomization Study Using Taiwan Biobank. Mayo Clinic proceedings S0025-6196(23), 23 (2023) [JCR] [WOS]
POSTDOC
Hsiao-Lin, Lee
RESEARCH ASSOCIATES
Jing-Yong, Huang
Chou, Yun Ju
Lee, Mei-Hua
STUDENTS
Chu-Hsien, Chou
Gwo-Tsann, Chuang
Yang, Wei-Shun
Che, Tony Pan-Hou
Kuo, Yu Chieh
Lee, Jiin Horng
ALUMNI
Cai-Cing, Liu
Meng-Lun, Hsieh
Wei-Lun, Su
Tung-Yuan, Lee
