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Dr. Lee, Yungling Leo

Research Fellow
  • 02-27899132 (Lab) (Room No: N343)
  • 02-26523013 (Office)
  • 02-27829142 (Fax)
Specialty:

1. Adaptive Immunity

2. Omics and Precision Medicine

3. Antigen Presenting Cells

4. Vaccine Development

Education and Positions:

  • M.D. National Taiwan University

    Ph.D. National Cheng Kung University

Clinical Immunology Lab: linking innate cells to adaptive immunity

 

T cell Regulation in Inflammatory Diseases

1. We have demonstrated that UVB-exposed Treg cells contributed to the alleviation of inflammatory skin in a murine model of OVA-induced skin inflammation under UVB irradiation. When depleting Treg cells in Foxp3DTR/GFP mice by the administration of diphtheria toxin, we found UVB irradiation could not suppress OVA-induced skin inflammation. In addition, we found that LAG-3 expression was significantly increased in UVB-exposed Treg cells.

 

2. Cytokine signaling between keratinocytes and innate cells results in CD4/CD8/Treg cell infiltration of psoriasis lesions. We applied single-cell mass cytometry (Cytometry Time-Of-Flight, CyTOF) to investigate function of Treg cells in the peripheral blood of patients with psoriasis. We will also apply single-cell RNA sequencing (scRNA-seq) to dissect the differential pattern among skin cells of patients before and after UVB therapy.

 

DC-based Cancer Immunotherapy

1. Emerging evidence suggests the promoting role of aromatic hydrocarbon receptor (AhR) in the initiation, promotion, progression, invasion, and metastasis of cancer cells. AhR-CD11c-conditional KO mice were generated and we found tumor growth were significantly reduced in conditional KO mice. It was also noted that activation of AhR can induce PD-L1 level on dendritic cell (DC) and Treg recruitment.

 

2. We employed phage display to select anti-CD11c peptide and AhR-neutralizing single-chain fragment variable (ScFv). PEGylated peptide is inserted into surface of liposome and the transcript of neutralizing ScFv is packaged in the inner space of liposome. Liposome coats acid-labile PEG-PGA-HX to prevent systemic peptidase and accelerating endosomal escape in acidic tumor microenvironment. Finally, we implemented the humanized ASID mice to investigate the efficiency of liposomal drugs. The DC-targeted cancer treatment remodels the tumor microenvironment and reduces side effects.

 

Our Team
Team photo

Journal 103 Book 2

  1. Yeh CY, Su SH, Tan YF, Tsai TF, Liang PH, Kelel M, Weng HJ, Hsiao YP, Lu CH, Tsai CH, Lee CH, Clausen BE, Liu FT, Lee YL* PD-L1 Enhanced by cis-Urocanic Acid on Langerhans Cells Inhibits Vγ4+ γδT17 Cells in Imiquimod-Induced Skin Inflammation. JOURNAL OF INVESTIGATIVE DERMATOLOGY 143, 1449-1460 (2023-08) [JCR] [WOS]
  2. Tsai CH, Lai AC, Lin YC, Chi PY, Chen YC, Yang YH, Chen CH, Shen SY, Hwang TL, Su MW, Hsu IL, Huang YC, Maitland-van der Zee AH, McGeachie MJ, Tantisira KG, Chang YJ, Lee YL* Neutrophil extracellular trap production and CCL4L2 expression influence corticosteroid response in asthma. SCIENCE TRANSLATIONAL MEDICINE 15(699), eadf3843 (2023-06) [JCR] [WOS]
  3. Chen CH, Lee YL, Wu MH, Chen PJ, Wei TS, Tseng CI, Chen WJ Prenatal household incense burning, air purifiers and cord blood IgE. CLINICAL AND EXPERIMENTAL ALLERGY 53(4), 474-478 (2023-04) [JCR] [WOS]
  4. Tsai MC, Lee YL*, Chen YC* Association of the consumption of common drinks with early puberty in both sexes. FRONTIERS IN PUBLIC HEALTH 10, 854477 (2022-12) [JCR] [WOS]
  5. Chen YC, Huang YT, Pan WH, Lee YL* Mediators linking obesity to childhood asthma. PEDIATRIC ALLERGY AND IMMUNOLOGY e13859 (2022-10) [JCR] [WOS]
  6. Chen YC, Su MW, Brumpton BM, Lee YL* Investigating obesity-related risk factors for childhood asthma. PEDIATRIC ALLERGY AND IMMUNOLOGY e13710, e13710 (2022-01) [JCR] [WOS]
  7. Chen CH, Lee YL, Wu MH, Chen PJ, Wei TS, Tseng CI, Chen WJ Prenatal antioxidant-enriched and pro-oxidant-contained food, IL4 and IL13 pathway genes, and cord blood IgE.. Scientific reports 12(1), 2884 (2022) [JCR] [WOS]
  8. Huang L, Wang ST, Kuo HP, Delclaux C, Jensen ME, Wood LG, Costa D, Nowakowski D, Oliveira PD, Chen YC, Chen YC*, Lee YL* Effects of Obesity on Pulmonary Function Considering the Transition from Obstructive to Restrictive Pattern from Childhood to Young Adulthood. OBESITY REVIEWS e13327, e13327 (2021-12) [JCR] [WOS]
  9. Chen YC, Kuo HP, Hsia SM, Wu HT, Pan WH, Lee YL* Life course body mass index through childhood and young adulthood and risks of asthma and pulmonary function impairment. PEDIATRIC PULMONOLOGY 56, 849-857 (2021-05) [JCR] [WOS]
  10. Kelel M, Yang RB, Tsai TF, Liang PH, Wu FY, Huang YT, Yang MF, Hsiao YP, Wang LF, Tu CF, Liu FT, Lee YL* FUT8 Remodeling of EGFR Regulates Epidermal Keratinocyte Proliferation during Psoriasis Development. Journal of Investigative Dermatology 141, 512-522 (2021-03) [JCR] [WOS]
- More Publications-

1. Outstanding Asian Young Environmental Epidemiologist Award, International Society of Environmental Epidemiology (2006)

2. Outstanding Young Physician Award, Taiwan Environmental and Occupational Medicine Association (2008)

3. Ta-You Wu Memorial Award, Ministry of Science and Technology (2015)

4. Tien-Te Lee Young Medical Scientist Award (2016)

5. Outstanding Research Award for Excellence in Medical Research, National Taiwan University Hospital (2018)

6. Outstanding Research Award, Ministry of Science and Technology (2019)