Dr. Shih, Hsiu-Ming
Research Fellow
- 2789-9060 (Lab) (Room No: N605)
- 2652-3520 (Office)
- 2782-7654 (Fax)
-
Specialty:
- Protein-protein Interaction & Modification
- Cancer Cell Signaling
- Transcriptional Control
Education and Positions:
Ph.D. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota
Highlight Detail
Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response.
Dr. Shih, Hsiu-Ming
EMBO J., Feb 08, 2013While numerous small ubiquitin-like modifier (SUMO) conjugated substrates have been identified, very little is known about the cellular signalling mechanisms that differentially regulate substrate sumoylation. Here, we show that acetylation of SUMO E2 conjugase Ubc9 selectively downregulates the sumoylation of substrates with negatively charged amino acid-dependent sumoylation motif
Preview article highlight