Dr. Chau, Lee-Young 's publons link picture

Dr. Chau, Lee-Young

Emeritus Research Fellow

  • Cardiovascular/Cancer Disease
  • Inflammation

Education and Positions:
  • Ph.D. University of Kentucky

Highlight Detail

TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation.

Dr. Chau, Lee-Young
Oncogene., Jun 11, 2012

The TRC8 gene, which was previously shown to be disrupted by a 3;8 chromosomal translocation in hereditary kidney cancer, encodes for an endoplasmic reticulum-resident E3 ligase. Studies have shown that TRC8 exhibits a tumor-suppressive effect through its E3-ligase activity. Therefore, the identification of its physiological substrates will provide important insights into the molecular mechanism underlying TRC8-mediated tumor suppression.