Dr. Chau, Lee-Young 's publons link picture

Dr. Chau, Lee-Young

Emeritus Research Fellow

  • Cardiovascular/Cancer Disease
  • Inflammation

Education and Positions:
  • Ph.D. University of Kentucky

Highlight Detail

Ubiquitin-proteasome system mediates heme oxygenase-1 degradation through endoplasmic reticulum-associated degradation pathway.

Dr. Chau, Lee-Young
Biochim Biophys Acta., May 21, 2008

The present study investigated the cellular mechanism underlying the degradation of heme oxygenase-1 (HO-1), an endoplasmic reticulum (ER)-anchored protein. The turnover of HO-1 induced in vascular smooth muscle cells (VSMCs) was significantly attenuated by proteasome inhibitors, suggesting the involvement of a proteasome-mediated pathway. High molecular weight ubiquitin conjugates were co-immunoprecipitated with HO-1 from VSMCs after proteasome inhibition, and HO-1 ubiquitination was confirmed in HEK293 cells overexpressing His-tagged HO-1 and