Dr. Cheng, Ching-Feng 's publons link picture

Dr. Cheng, Ching-Feng

Joint Appointment Associate Research Fellow
  • 02-2789-9135 (Lab) (Room No: N706)

  • Integrative Physiology
  • Molecular Cardiology
  • Metabolic syndrome

Education and Positions:
  • M.D., Taipei Medical University

    Post Doctoral Fellowship, Kenneth R. Chien Lab, UCSD, U.S.A

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Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3

Dr. Cheng, Ching-Feng
Communications Biology, Oct 24, 2019

Billions of people have obesity-related metabolic syndromes such as diabetes and hyperlipidemia. Promoting the browning of white adipose tissue has been suggested as a potential strategy, but a drug still needs to be identified. Here, genetic deletion of activating transcription factor 3 (ATF3−/−) in mice under a high-fat diet (HFD) resulted in obesity and insulin resistance, which was abrogated by virus-mediated ATF3 restoration. ST32da, a synthetic ATF3 inducer isolated from Salvia miltiorrhiza, promoted ATF3 expression to downregulate adipokine genes and induce adipocyte browning by suppressing the carbohydrate-responsive element-binding protein–stearoyl-CoA desaturase-1 axis. Furthermore, ST32da increased white adipose tissue browning and reduced lipogenesis in HFD-induced obese mice. The anti-obesity efficacy of oral ST32da administration was similar to that of the clinical drug orlistat. Our study identified the ATF3 inducer ST32da as a promising therapeutic drug for treating diet-induced obesity and related metabolic disorders.