M.D., Taipei Medical University
Post Doctoral Fellowship, Kenneth R. Chien Lab, UCSD, U.S.A
With the growth of genetic engineering, mice have become common models of human cardiovascular disease and therefore have stimulated the development of techniques to monitor and image the murine cardiovascular system. We had established techniques with cardiac trans-aortic banding, coronary artery ligation, cardiac ischemic reperfusion, and has established the following in vivo analysis in the past several years including surface ECG, echocardiography, wireless radio-telemetry and heart rate variability studies. Through collaboration with colleagues in our Institute, we have worked on several models of cardiovascular diseases (ATF3). In addition, we had identified the molecules (drug screening) that can promote ATF3 induction and determine their possible clinical application to reverse HFD-induced obesity and related disease.
Green tea epigallocatechin gallate inhibits preadipocyte growth via the microRNA-let-7a/HMGA2 signaling pathwayMolecular Nutrition & Food Research, Feb 24, 2023
The ATF3 inducer protects against diet-induced obesity via suppressing adipocyte adipogenesis and promoting lipolysis and browningBiomedicine & Pharmacotherapy, Nov 25, 2021