Dr. Fann, Cathy S.-J. 's publons link picture Dr. Fann, Cathy S.-J. 's Personal Homepage

Dr. Fann, Cathy S.-J.

Research Fellow
  • 02-27899144 (Lab) (Room No: 100)
  • 02-27823047 (Fax)

  • Genetic Statistics
  • Genetic Epidemiology

Education and Positions:
  • Division of Biostatistics, Department of Preventive Medicine and Environmental Health,
    Ph.D. University of Iowa, Iowa City, Iowa, US

Highlight Detail

Genome-wide association study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan.

Dr. Fann, Cathy S.-J.
Cephalalgia., Mar 01, 2018

Susceptibility genes for migraine, despite it being a highly prevalent and disabling neurological disorder, have not been analyzed in Asians by genome-wide association study (GWAS). Methods We conducted a two-stage case-control GWAS to identify susceptibility genes for migraine without aura in Han Chinese residing in Taiwan. The present study is the first migraine GWAS conducted in Han-Chinese and Asians. The newly identified susceptibility genes have potential implications in migraine pathogenesis. DLG2 is involved in glutamatergic neurotransmission, and GFRA1 encodes GDNF receptors that are abundant in CGRP-containing trigeminal neurons. Furthermore, positive association signals for TRPM8 and LRP1 suggest the possibility for common genetic contributions across ethnicities.