Biomaterials and Nanotechnology for Drug and Vaccine Development
B.S. University of California, Berkeley (Biomedical Engineering)
Ph.D. University of California, San Diego (Bioengineering)
Antigen-specific lung-resident memory T cells (Ts) constitute the first line of defense that mediates rapid protection against respiratory pathogens and inspires novel vaccine designs against infectious pandemic threats, yet effective means of inducing Ts, particularly via non-viral vectors, remain challenging. Here, we demonstrate safe and potent induction of lung-resident T and CD8 induction as well as the benefit of subcutaneous priming on T replenishment. The study presents a practical vaccination strategy for inducing protective T-mediated immunity, offering a compelling platform and critical insights in the ongoing quest toward a broadly protective vaccine against universal influenza as well as other respiratory pathogens.