Dr. Yang, Shi-Bing 楊世斌 博士

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Dr. Yang, Shi-Bing
楊世斌 博士

Assistant Research Fellow
助研究員

Specialty:
  • Neurophysiology
  • Energy Metabolism
  • Ion channels

RESEARCH

Ion channels are membrane proteins that allow certain ions to rapidly cross the membrane. The orchestrated activities of ion channels generate various bioelectric phenomena, including nerve signal propagation, muscle contraction, and hormone release. Moreover, large-scale genetic analyses have identified ion channel mutations that are associated with human diseases. Combining patch-clamp recording with molecular and cell biology, our laboratory is interested in investigating the basic mechanisms that govern ion channel functions and exploring the roles of ion channels under physiological and pathological conditions. Currently, we are focusing on the ion channel mutations that are associated with diseases of the endocrine and nervous systems.

 

研究介紹

離子通道為一群特殊的膜蛋白,不同離子可經由特定的離子通道進出細胞內外。除此之外,透過離子通道的協同運作,會產生不同的生物電現象,例如神經訊號傳導,肌肉收縮以及激素的釋放。最近的大尺度流行病遺傳學分析找出許多致病的離子通道突變,本實驗室藉由結合分子生物學、小鼠遺傳學以及膜片鉗技術,來探討離子通道的基本運作原理,以及離子通道在各式生理以及病理狀態下所扮演的角色。目前主要著重於導致神經系統以及內分泌系統疾病相關離子通道突變的研究。

HIGHLIGHT 重要成果

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