Dr. Lee, Te-Chang 李德章 博士

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Dr. Lee, Te-Chang
李德章 博士

Adjunct Research Fellow
兼任研究員



  • Ph.D. National Taiwan University

  • 02-27899145 (Lab) (Room No: N247)
  • 02-26523055 (Office)
  • 02-27829142 (Fax)
Specialty:
  • Genetic and Molecular Toxicology
  • Cancer Biology
  • Pharmacology
  • Biobank

RESEARCH

My current research focuses on the development of novel anticancer drugs. Via collaboration with Dr. T. L. Su, a medicinal chemist in IBMS, we have demonstrated that several newly synthesized bifunctional alkylating agents are potent anticancer agents. Several of them were even able to overcome the MDR cancer cells. Our recent interest is to design hybrid molecules with dual functions. We have successfully conjugated phthalazine and bis(hydroxymethyl)pyrrole pharmacophores to form hybrids bearing antiangiogenesis and DNA interstrand crosslinking activities. We have demonstrated these hybrids displaying a broad-spectrum anticancer activity.

I served as PI of Taiwan Biobank (https://www.twbiobank.org.tw). The Taiwan Biobank is a national scientific infrastructure providing the biomedical research community access to biological specimens and information collected from the genereal population in Taiwan. The objective Taiwan Biobank is to recruit 200,000 voluntary participants. Currently, we have recruited 148,291 participants and produced more than 100,000 whole genome genotyping. 

研究介紹

本研究室近年來聚焦於研發新穎抗癌藥物。經與本所醫藥化學家蘇燦隆博士之合作,近年來我們驗證許多新合成雙官能烷化劑的抗癌活性,部分化合物甚具抑制多重抗藥性癌細胞之活性。最近的興趣為設計合成具有雙功能的雜合分子。現已成功將具抑制血管新生之酞嗪與可造成DNA雙股連接之雙(羥甲基)吡咯接合成雜合分子,並驗證其具有廣效之抗癌作用。

本人亦擔任臺灣人體生物資料庫之代表人。臺灣人體生物資料庫之目標為收集20萬社區一般民眾之健康資訊與生物檢體,做為生醫研究之基盤建設。目前已收存超過14萬人之健康資訊及生物檢體,並可釋出超過 10萬筆全基因體定型之資料。


 

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