Dr. Chen, Chinpan 陳金榜 博士
Ph.D. University of Washington
My laboratory focuses on the structure/function study of biologically important proteins by using a variety of biophysical techniques.
PmrD and PmrA/PmrB two-component system from Klebsiella pneumonia: In bacteria the two-component signal-transduction system is the most prevalent system in response to environmental stresses for transducing the information inside the cells. Understanding the structural characterizations of PmrD and PmrA/PmrB two-component system may provide valuable information about the mechanism how Klebsiella pneumoniae resists the antimicrobial peptides, such as polymyxin B, which may be helpful in drug development for the infections related to K. pneumoniae.
DNA-binding proteins: Biophysical studies of the three-C2H2 zinc finger protein in TZFP (testis zinc finger protein) and of Myb1 and Myb3 protein from Trichomonas vaginalis are currently in the progress. Especially, determination of the DNA-bound complex structures will be carried out using heteronuclear multidimensional NMR techniques and computational modeling to further gain insights into structure/function relationships.
實驗室主要是利用生物物理實驗來探討結構與功能之相關性。
克雷伯氏菌PmrD和PmrA/PmrB雙分子系統: 細菌透過種種訊號傳導系統來適應環境的變化，其中最普遍的就是所謂雙分子系統。研究這些蛋白結構特性，將有助於瞭解克雷伯氏菌對抗菌勝肽等所產生的抗藥性機制，同時也能對感染性克雷伯氏菌的藥物發展有所幫助。
DNA結合蛋白：目前在進行DNA結合蛋白(three-C2H2 zinc finger， Myb1和Myb3) 的生物物理相關研究。尤其是利用異核多維NMR技術和電腦模擬計算定出蛋白/DNA複合物結構以便更深入瞭解結構與功能之關連性。
