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Dr. Huang, Yi-Shuian

Research Fellow
Division Chief
  • 02-2789-9174 (Lab) (Room No: N703)
  • 02-2652-3523 (Office)
Specialty:
  • Translational Control/ RNA 轉譯調控
  • Cap modification/ RNA-cap 修飾調控
  • Molecular & Cellular Neuroscience/ 分子與細胞神經生物學
Education and Positions:

  • Ph.D. University of Texas Southwestern Medical Center at Dallas

Neurons receive thousands of synaptic connections from others and modify the strength of individual synapses independently with varying degrees of stability. This experience-dependent synaptic plasticity underlies the molecular and cellular basis of learning and memory. Regulated local translation allows for remote control of gene expression to concentrate proteins in subcellular compartments such as synapses and is important for synaptic plasticity and memory. Thus, we study cytoplasmic polyadenylation element binding proteins (CPEBs), which regulate the translation of target mRNAs for memory and other physiological functions.

 

Several chemical modifications in mRNAs have been identified to regulate posttranscriptional gene expression. However, the mechanisms underlying epitranscriptome-controlled translation remain largely unexplored. Thus, we also investigate the molecular and physiological functions of cap methyltransferases (CMTRs). Eukaryotic mRNAs are 5'-end capped with a 7-methylguanosine (m7GpppNN, N: any nucleotide), which is important for processing, transport, and translation of mRNAs. The cap structure in higher eukaryotes is further methylated at the 2'-O-ribose position of the first and second nucleotides by CMTR1 and CMTR2. The cap1 structure (m7GpppNmN) is generally believed to mask mRNAs from innate immune surveillance. However, we found that CMTR1-catalyzed 2'-O-methylation is important for gene regulation and brain development independent of silencing innate immunity.

 

Our Team
Team photo

Journal 64 Book 0

  1. Chao YW, Lee YL, Tseng CS, Wang LU, Hsia KC, Chen H, Fustin JM, Azeem S, Chang TT, Chen CY, Kung FC, Hsueh YP*, (Huang YS)*, Chao HW* Improved CaP Nanoparticles for Nucleic Acid and Protein Delivery to Neural Primary Cultures and Stem Cells. ACS nano (2024) [JCR] [WOS]
  2. (Huang YS)*, Mendez R*, Fernandez M, Richter JD* CPEB and translational control by cytoplasmic polyadenylation: impact on synaptic plasticity, learning, and memory. Molecular psychiatry (2023) [JCR] [WOS]
  3. Tseng CS, Chao YW, Liu YH, (Huang YS)*, Chao HW* Dysregulated proteostasis network in neuronal diseases. Frontiers in cell and developmental biology 11, 1075215 (2023) [JCR] [WOS]
  4. Tsukamoto Y, Hiono T, Yamada S, Matsuno K, Faist A, Claff T, Hou J, Namasivayam V, Vom Hemdt A, Sugimoto S, Ng JY, Christensen MH, Tesfamariam YM, Wolter S, Juranek S, Zillinger T, Bauer S, Hirokawa T, Schmidt FI, Kochs G, Shimojima M, (Huang YS), Pichlmair A, Kummerer BM, Sakoda Y, Schlee M, Brunotte L, Muller CE, Igarashi M, Kato H Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication. SCIENCE 379(6632), 586-591 (2023) [JCR] [WOS]
  5. Winkler I, Engler JB, Vieira V, Bauer S, Liu YH, Di Liberto G, Grochowska KM, Wagner I, Bier J, Bal LC, Rothammer N, Meurs N, Egervari K, Schattling B, Salinas G, Kreutz MR, (Huang YS), Pless O, Merkler D, Friese MA MicroRNA-92a-CPEB3 axis protects neurons against inflammatory neurodegeneration. Science advances 9(47), eadi6855 (2023) [JCR] [WOS]
  6. Wu CS, Lu WH, Hung MC, (Huang YS)*, Chao HW* From polyploidy to polyploidy reversal: its role in normal and disease states. Trends in genetics : TIG 38(10), 991-995 (2022) [JCR] [WOS]
  7. Lai HH, Hung LY, Yen CJ, Hung HC, Chen RY, Ku YC, Lo HT, Tsai HW, Lee YP, Yang TH, Chen YY, Huang YS, Huang W NEIL3 promotes hepatoma epithelial-mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway. The Journal of pathology 258(4), 339-352 (2022) [JCR] [WOS]
  8. Huang DF, Lee CY, Chou MY, Yang TY, Cao X, Hsiao YH, Wu RN, Lien CC, (Huang YS), Huang HP, Gau SS, Huang HS Neuronal splicing regulator RBFOX3 mediates seizures via regulating Vamp1 expression preferentially in NPY-expressing GABAergic neurons. Proceedings of the National Academy of Sciences of the United States of America 119(33), e2203632119 (2022) [JCR] [WOS]
  9. Lu WH, Chang YM, (Huang YS*) Alternative Polyadenylation and Differential Regulation of Ucp1: Implications for Brown Adipose Tissue Thermogenesis Across Species. Frontiers in pediatrics 8, 612279 (2021) [JCR] [WOS]
  10. Lu WH, Chao HW, Lin PY, Lin SH, Liu TH, Chen HW, (Huang YS*) CPEB3-downregulated Nr3c1 mRNA translation confers resilience to developing posttraumatic stress disorder-like behavior in fear-conditioned mice Neuropsychopharmacology 46, 1669-1679 (2021) [JCR] [WOS]
- More Publications-

- POSTDOC -
Lu, Wen-Hsin
Lu, Wen-Hsin
Chen, Ying-Da
Chen, Ying-Da
- RESEARCH ASSOCIATES -
Hussain, Akhlaq
Hussain, Akhlaq
Liu, Tzu Hsien
Liu, Tzu Hsien
Lai, Yi-An
Lai, Yi-An
Chang, Tzu-Tung
Chang, Tzu-Tung
Kung, Fen-Che
Kung, Fen-Che
Hsu, Yu-Hsuan
Hsu, Yu-Hsuan
Tan, Mao-Jia
Tan, Mao-Jia
- STUDENTS -
Azeem, Sayma
Azeem, Sayma
Aritonang, Imelda Margaretha
Aritonang, Imelda Margaretha
- ALUMNI -
Lai, Yen-Ting
Lai, Yen-Ting
Hsu, Chen-Ming
Hsu, Chen-Ming
Chen, Yi-ting
Chen, Yi-ting
Chen, Hui Feng
Chen, Hui Feng
Lin, Chia-Hsuan
Lin, Chia-Hsuan
Tseng, Ching-San
Tseng, Ching-San
Chen, Chin-Yi
Chen, Chin-Yi
Chao, Hsu-Wen
Chao, Hsu-Wen
Wu, Meng-Fang
Wu, Meng-Fang
Yeh, Nai-Hsing
Yeh, Nai-Hsing
Lee, Yen-Lurk
Lee, Yen-Lurk
Chang, Yu-Wei
Chang, Yu-Wei
Lin, TeLin
Lin, TeLin
member
Lin, Hui-Min
member
Chen, Yan-Chu
member
Fan, Bo-Yao
MOSNAZ, A.T.M. JANNATUL
MOSNAZ, A.T.M. JANNATUL
King, Pei-Chih
King, Pei-Chih
Young, Melody
Young, Melody