RESEARCH
Our laboratory is aimed to explore the molecular mechanism of lung carcinogenesis and personalized therapy of lung cancer, which is the most important and endemic cancer in Taiwan. We focus on the following areas:
1. Functional genomics and translational research of lung cancer.
2. Molecular mechanism of EMT and cancer metastasis.
3. Biomarker and personalized therapy of lung cancer.
We have established lung cancer cell lines with different driver mutations and invasion/metastasis lung cancer cell line model. To reduce lung cancer mortality and improve treatment outcome, We establish national reference laboratory, provide standardized and high quality gene testing for all lung cancer patients. With the implementation of nation-wide gene testing and personalized therapy, the overall 5-year survival for NSCLC has been improved from 15.8% to 31.6% from 2009 to 2013. We also identified the susceptible gene loci for non-smoker lung adenocarcinoma in East Asia. Currently we are working on oncogenic mechanism and regulatory pathways involved in tumor progression and metastasis. We specifically focus on the EGFR signaling pathway. We are also developing new targeted therapy and decipher the mechanisms of drug resistance. We hope our discovery can provide further understanding of lung carcinogenesis and help to develop new therapeutics for lung cancer patients.
研究介紹
本實驗室的研究重點主要有下列三個方向
(1)國人肺癌的基因體及轉譯醫學研究。
(2)癌轉移之分子調控機制。
(3)肺癌之生物標誌及個人化醫療。
我們以國人不抽菸肺腺癌為主要研究重點，並以全基因體相關性研究，基因微陣列、蛋白體及代謝體等技術，利用肺癌病人之組織及血液檢體及所建立之國人肺癌之細胞株，找出國人肺腺癌之相關危險基因，可能的致癌基因及相關訊息傳遞途徑，特別針對EGFR訊息傳遞途徑在國人肺腺癌發生之角色。
本實驗室也參與發展新的標靶治療及研發解決肺癌藥物治療抗藥性之問題等，進一步了解國人肺腺癌之發病機制及並期能發展創新治療方式及防治策略，以協助解決國人肺腺癌之重要健康問題。
