Dr. Lee, Te-Chang 李德章 博士

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  • Arsenic trioxide-mediated suppression of miR-182-5p is associated with potent anti-oxidant effects through up-regulation of SESN2
    Oncotarget, Mar 23, 2018
    Arsenic trioxide (ATO) is a traditional Chinese medicine that can induce oxidative stress for treatment of cancer cells. However, ATO may ge ......
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  • A Low-Toxicity DNA-Alkylating N-Mustard-Quinoline Conjugate with Preferential Sequence Specificity Exerts Potent Antitumor Activity Against Colorectal Cancer
    Neoplasia, Dec 13, 2017
    Efficacy and safety are fundamental prerequisites for anticancer drug development. In the present study, we explored the anti–colorect ......
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  • Promoter hypermethylation of LGALS4 correlates with poor prognosis in patients with urothelial carcinoma
    Oncotarget, Apr 04, 2017
    Galectine-4 (gal-4), encoded by the LGALS4 gene, was recently shown to exhibit a tumor suppressive effect in colorectal carcinoma and pancre ......
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  • P-glycoprotein attenuates DNA repair activity in multidrug-resistant cells by acting through the Cbp-Csk-Src cascade
    Oncotarget, Feb 03, 2017
    Recent studies have demonstrated that P-glycoprotein (P-gp) expression impairs DNA interstrand cross-linking agent-induced DNA repair effici ......
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