Dr. Tarn, Woan-Yuh
Distinguished Research Fellow
- 02-27899015 (Lab) (Room No: N223)
- 02-26523052
- 02-27829142 (Fax)
-
Specialty:
- mRNA splicing in neuron
- translational control in cancer
- long non-coding RNA
Education and Positions:
Ph.D. National Tsing Hua University
Postdoc Assoc. Yale University
Highlight Detail
RBM4 Promotes Pancreas Cell Differentiation and Insulin Expression.
Dr. Tarn, Woan-Yuh
Mol Cell Biol., Jan 13, 2013The RNA-binding protein RNA-binding motif protein 4 (RBM4) modulates alternative splicing of muscle-specific mRNA isoforms during muscle cell differentiation. To better understand the physiological function of RBM4, we exploited a gene knockout strategy in the present study. Mice with targeted disruption of one of the two Rbm4 genes exhibited hyperglycemia coincident with reduced levels of serum insulin and reduced size of pancreatic islets.