Dr. Tarn, Woan-Yuh 譚婉玉 博士

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RBM4 Promotes Pancreas Cell Differentiation and Insulin Expression.

Mol Cell Biol., Jan 13, 2013

The RNA-binding protein RNA-binding motif protein 4 (RBM4) modulates alternative splicing of muscle-specific mRNA isoforms during muscle cell differentiation. To better understand the physiological function of RBM4, we exploited a gene knockout strategy in the present study. Mice with targeted disruption of one of the two Rbm4 genes exhibited hyperglycemia coincident with reduced levels of serum insulin and reduced size of pancreatic islets.

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