Dr. Tarn, Woan-Yuh
Distinguished Research Fellow
- 02-27899015 (Lab) (Room No: N223)
- 02-26523052
- 02-27829142 (Fax)
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Specialty:
- mRNA splicing in neuron
- translational control in cancer
- long non-coding RNA
Education and Positions:
Ph.D. National Tsing Hua University
Postdoc Assoc. Yale University
Highlight Detail
The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene.
Dr. Tarn, Woan-Yuh
MCB., Sep 15, 2008Spinal muscular atrophy (SMA) is a recessive neuromuscular disorder caused by the homozygous loss of the SMN1 gene. The human SMN2 gene has a C-to-T transition at position +6 of exon 7 and thus produces exon 7-skipping mRNAs. However, we observed an unexpectedly high level of exon 7-containing SMN2 transcripts as well as SMN protein in testis of smn-/-SMN2 transgenic mice.