Dr. Chen, Chinpan
Emeritus Research Fellow
- 02-26523035 (Lab) (Room No: N133)
- 02-27887641 (Fax)
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Specialty:
- Structural Biology
- NMR
Education and Positions:
Ph.D. University of Washington
Highlight Detail
Structure of the Trichomonas vaginalis Myb3 DNA-binding domain bound to a promoter sequence reveals a unique C-terminal β-hairpin conformation
Dr. Chen, Chinpan
Nucl. Acids Res., Sep 08, 2011Trichomonas vaginalis Myb3 transcription factor (tvMyb3) recognizes the MRE-1 promoter sequence and regulates ap65-1 gene, which encodes a hydrogenosomal malic enzyme that may play a role in the cytoadherence of the parasite. Here, we identified tvMyb353–180 as the essential fragment for DNA recognition and report the crystal structure of tvMyb353–180 bound to MRE-1 DNA.