Dr. Chern, Yijuang 陳儀莊 博士

List of Highlights
文件紀錄

• The Impact of Dysregulated microRNA Biogenesis Machinery and microRNA Sorting on Neurodegenerative Diseases

  International Journal of Molecular Sciences Feb 08, 2023

• Deletion of equilibrative nucleoside transporter 2 disturbs energy metabolism and exacerbates disease progression in an experimental model of Huntington's disease

  Neurobiology of Disease Jan 17, 2023

• TRAX Provides Neuroprotection for Huntington's Disease Via Modulating a Novel Subset of MicroRNAs

  Movement Disorders Aug 23, 2022

• A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis

  Movement Disorders Dec 23, 2021

• Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases

  Journal of Biomedical Science Oct 11, 2021

• A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS

  Neurobiology of Disease Oct 08, 2021

• Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases

  Frontiers in Cellular Neuroscience Jul 28, 2021

• Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy

  Acta Neuropathologica Communications Jun 25, 2021

• Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors

  Translational Psychiatry Aug 27, 2019

• Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease

  Nature Communications Aug 02, 2019

• Enhanced Na+‐K+‐2Cl‐ cotransporter 1 underlies motor dysfunction in huntington's disease

  MOVEMENT DISORDERS Mar 06, 2019

• Degeneration of ipRGCs in mouse models of Huntington's Disease disrupts non-image forming behaviors prior to motor impairment

  Journal of Neuroscience Dec 26, 2018

• Microglial Lectins in Health and Neurological Diseases

  Frontiers in Molecular Neuroscience May 14, 2018

• Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease

  Molecular Neurobiology Apr 04, 2018

• GSK3β negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons

  Molecular Psychiatry Jan 03, 2018

• Altered behavioral responses to gamma-aminobutyric acid pharmacological agents in a mouse model of Huntington's disease

  Movement disorders Aug 07, 2017

• Energy Homeostasis and Abnormal RNA Metabolism in Amyotrophic Lateral Sclerosis

  Frontiers in Cellular Neuroscience May 04, 2017

• Targeting ENT1 and adenosine tone for the treatment of Huntington’s disease

  Human Molecular Genetics Jan 09, 2017

• Elucidating the role of the A_2A adenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs.

  Hum. Mol. Genet. Aug 11, 2015

• A central role of TRAX in the ATM-mediated DNA repair.

  Oncogene. Jun 22, 2015

• Aberrant astrocytes impair vascular reactivity in huntington's disease.

  Ann Neurol. Apr 25, 2015

• Activation of AMP- activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.

  Hum Mol Genet. Sep 25, 2014

• Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease.

  Hum Mol Genet. Apr 03, 2014

• The A_2A adenosine receptor is a dual-coding gene: a novel mechanism of gene usage and signal transduction.

  JBC Nov 29, 2013

• Lack of Type VI Adenylyl Cyclase (AC6) Leads to Abnormal Sympathetic Tone in Neonatal Mice.

  Exp Neurol. May 28, 2013

• A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease.

  Hum Mol Genet. Jan 30, 2013

• Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB.

  Cell Mol Life Sci. May 25, 2012

• Type VI adenylyl cyclase (AC6) regulates neurite extension by binding to Snapin and Snap25.

  Mol. Cell. Biol. Oct 10, 2011

• Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington』s disease.

  JCB Jul 18, 2011

• Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease.

  J Clin Invest. Mar 14, 2011

• Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma.

  Human Molecular Genetics Aug 06, 2010

• The A_2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system

  Human Molecular Genetics Advance Access May 14, 2009

• Expanded-Polyglutamine Huntingtin Protein Suppresses the Secretion and Production of a Chemokine (CCL5/RANTES) by Astrocytes.

  J. of Neuroscience Mar 26, 2008

• Systematic uncovering of multiple pathways underlying the pathology of Huntington's disease by an acid-cleavable isotope-coded affinity tag approach.

  Molecular & Cellular Proteomics. Jan 31, 2007

• Dysregulation of C/EBPa by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease.

  Hum Mol Genet. Jan 09, 2007