Dr. Shieh, Sheau-Yann
Research Fellow
- 02-26523916 (Lab) (Room No: N347)
- 02-27829143 (Fax)
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Specialty:
- Cancer Cell Biology
- Cell Cycle Signaling
Education and Positions:
Ph.D. Baylor College of Medicine Post-doc:Columbia University
Highlight Detail
Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1.
Dr. Shieh, Sheau-Yann
PNAS, Mar 26, 2013B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG/ Transducer of ErbB2 gene family and is induced by genotoxic stress in a p53- and Checkpoint kinase 1 (CHK1)-dependent manner. Down-regulation of BTG3 has been observed in human cancers, suggesting that it plays an important role in tumor suppression, although the underlying mechanisms are unclear.